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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2009-7-29
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pubmed:abstractText |
To characterize a novel Asp384Asn (D384N) mutant myocilin (MYOC) that causes juvenile-onset open-angle glaucoma (JOAG) and investigate the correction of mutant phenotype by a natural osmolyte, trimethylamine N-oxide (TMAO).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/4-phenylbutylamine,
http://linkedlifedata.com/resource/pubmed/chemical/Aryl Hydrocarbon Hydroxylases,
http://linkedlifedata.com/resource/pubmed/chemical/Butylamines,
http://linkedlifedata.com/resource/pubmed/chemical/CYP1B1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 Enzyme System,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Eye Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Methylamines,
http://linkedlifedata.com/resource/pubmed/chemical/OPTN protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor TFIIIA,
http://linkedlifedata.com/resource/pubmed/chemical/WDR36 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/trabecular meshwork-induced...,
http://linkedlifedata.com/resource/pubmed/chemical/trimethyloxamine
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1552-5783
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3743-9
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19234343-Adult,
pubmed-meshheading:19234343-Aged,
pubmed-meshheading:19234343-Aged, 80 and over,
pubmed-meshheading:19234343-Apoptosis,
pubmed-meshheading:19234343-Aryl Hydrocarbon Hydroxylases,
pubmed-meshheading:19234343-Blotting, Western,
pubmed-meshheading:19234343-Butylamines,
pubmed-meshheading:19234343-Cytochrome P-450 Enzyme System,
pubmed-meshheading:19234343-Cytoskeletal Proteins,
pubmed-meshheading:19234343-DNA Mutational Analysis,
pubmed-meshheading:19234343-Dose-Response Relationship, Drug,
pubmed-meshheading:19234343-Eye Proteins,
pubmed-meshheading:19234343-Female,
pubmed-meshheading:19234343-Glaucoma, Open-Angle,
pubmed-meshheading:19234343-Glycoproteins,
pubmed-meshheading:19234343-Humans,
pubmed-meshheading:19234343-Intraocular Pressure,
pubmed-meshheading:19234343-Male,
pubmed-meshheading:19234343-Methylamines,
pubmed-meshheading:19234343-Middle Aged,
pubmed-meshheading:19234343-Mutagenesis, Site-Directed,
pubmed-meshheading:19234343-Mutation, Missense,
pubmed-meshheading:19234343-Pedigree,
pubmed-meshheading:19234343-Phenotype,
pubmed-meshheading:19234343-Protein Folding,
pubmed-meshheading:19234343-Transcription Factor TFIIIA,
pubmed-meshheading:19234343-Transfection,
pubmed-meshheading:19234343-Young Adult
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pubmed:year |
2009
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pubmed:articleTitle |
Correction of the disease phenotype of myocilin-causing glaucoma by a natural osmolyte.
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pubmed:affiliation |
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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