|
rdf:type |
|
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lifeskim:mentions |
umls-concept:C0032285,
umls-concept:C0379528,
umls-concept:C0392756,
umls-concept:C0700624,
umls-concept:C0871261,
umls-concept:C1423842,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1709059,
umls-concept:C1999216,
umls-concept:C2911692
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|
pubmed:issue |
10
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|
pubmed:dateCreated |
2009-5-8
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|
pubmed:abstractText |
Gamma-secretase inhibitor (GSI) has been used to effectively block Notch signaling, which is implicated in the differentiation and functional regulation of T helper (Th) effector cells. In asthma, a subset of CD4(+) T cells is believed to initiate and perpetuate the disease.
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|
pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
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pubmed:issn |
1535-4970
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|
pubmed:author |
|
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pubmed:issnType |
Electronic
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pubmed:day |
15
|
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pubmed:volume |
179
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
875-82
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pubmed:meshHeading |
pubmed-meshheading:19234107-Administration, Intranasal,
pubmed-meshheading:19234107-Amyloid Precursor Protein Secretases,
pubmed-meshheading:19234107-Animals,
pubmed-meshheading:19234107-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:19234107-Cytokines,
pubmed-meshheading:19234107-Drug Synergism,
pubmed-meshheading:19234107-Eosinophilia,
pubmed-meshheading:19234107-GATA3 Transcription Factor,
pubmed-meshheading:19234107-Male,
pubmed-meshheading:19234107-Mice,
pubmed-meshheading:19234107-Mice, Inbred BALB C,
pubmed-meshheading:19234107-NF-kappa B,
pubmed-meshheading:19234107-Oligopeptides,
pubmed-meshheading:19234107-Ovalbumin,
pubmed-meshheading:19234107-Pneumonia,
pubmed-meshheading:19234107-Receptors, Notch,
pubmed-meshheading:19234107-Respiratory Hypersensitivity,
pubmed-meshheading:19234107-Signal Transduction,
pubmed-meshheading:19234107-Th1 Cells,
pubmed-meshheading:19234107-Th2 Cells
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pubmed:year |
2009
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pubmed:articleTitle |
Gamma-secretase inhibitor reduces allergic pulmonary inflammation by modulating Th1 and Th2 responses.
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pubmed:affiliation |
Division of Molecular and Life Sciences, College of Science and Technology, Hanyang University, Seoul, South Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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