Linked Life Data

19233709

Source:http://linkedlifedata.com/resource/pubmed/id/19233709

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2009-7-17
pubmed:abstractText
Numerous studies have shown that the microtubule-associated protein tau (Mapt) gene plays an important role in tauopathies. However, little is known about the genetic regulatory network. In this study, we combined array analysis and quantitative trait loci (QTL) mapping approaches (genetical genomics) to characterize the expression variation and the regulatory network of Mapt in mouse. Through examining the probe sets for overlapping single nucleotide polymorphysms (SNPs), two probe sets without overlapping SNPs were selected for QTL mapping. Interval mapping results showed that expression quantitative trait loci (eQTL) mapping for Mapt had a significant linkage score (LRS) of 27.2. Moreover, the QTL was mapped to within 3 Mb of the location of the gene itself (Mapt) as a cis-acting QTL. Through mapping the joint modulation of Mapt, we identified 22 transcripts/genes with trans-regulated QTLs close to the location of Mapt. By further excluding the correlated transcripts due to linkage disequilibrium, the result highlighted three genes as potential downstream genes of Mapt. Expression correlation and genetic network analysis demonstrated that Mapt co-varies with many tauopathies-related genes, including Gsk3b, Falz, Apbb2, Slc1a3, Ntrk2, Pik3ca, and Ikbkap. These results demonstrate that the genetical genomics approach provides a powerful tool for constructing pathways that contribute to complex traits, such as neurodegenerative disorders.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1873-5126
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
525-31
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Expression QTL and regulatory network analysis of microtubule-associated protein tau gene.
pubmed:affiliation
Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong 226001, PR China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural