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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2009-3-9
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pubmed:abstractText |
This letter describes the total synthesis, preliminary biological evaluation and mechanism studies of a novel and structurally unique isochromanone, (+/-)7,8-dihydroxy-3-methyl-isochromanone-4 (1), a nature product contained in banana (Musa sapientum L.) peel. The bioassay showed that compound 1 displays potent antihypertensive activity in renal hypertensive rats and further mechanism studies revealed that it is an ACE inhibitor.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:BaiRenrenR,
pubmed-author:FuJihuaJ,
pubmed-author:FuRongR,
pubmed-author:HuangWenlongW,
pubmed-author:LeeL FLF,
pubmed-author:QiYanY,
pubmed-author:ThuH DHD,
pubmed-author:WangQiujuanQ,
pubmed-author:WuQianQ,
pubmed-author:WuXiaomingX,
pubmed-author:XuJinyiJ
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1822-4
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pubmed:meshHeading |
pubmed-meshheading:19233642-Angiotensin-Converting Enzyme Inhibitors,
pubmed-meshheading:19233642-Animals,
pubmed-meshheading:19233642-Antihypertensive Agents,
pubmed-meshheading:19233642-Chemistry, Pharmaceutical,
pubmed-meshheading:19233642-Chromones,
pubmed-meshheading:19233642-Drug Design,
pubmed-meshheading:19233642-Hypertension, Renal,
pubmed-meshheading:19233642-Liver,
pubmed-meshheading:19233642-Models, Chemical,
pubmed-meshheading:19233642-Molecular Structure,
pubmed-meshheading:19233642-Musa,
pubmed-meshheading:19233642-Plant Extracts,
pubmed-meshheading:19233642-Rats,
pubmed-meshheading:19233642-Structure-Activity Relationship
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pubmed:year |
2009
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pubmed:articleTitle |
Total synthesis and antihypertensive activity of (+/-)7,8-dihydroxy-3-methyl-isochromanone-4.
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pubmed:affiliation |
Department of Medicinal Chemistry, China Pharmaceutical University, Tongjia Xiang 24, Nanjing, Jiangsu 210009, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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