Linked Life Data

19233632

Source:http://linkedlifedata.com/resource/pubmed/id/19233632

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-4-13
pubmed:abstractText
Intervention in protein kinase C (PKC) has a chequered history, partly because of the poor selectivity of many inhibitors and partly a reflection of the sometimes antagonistic action of related PKC isoforms. Recent advances in targeting PKC isoforms have come from structural work on isolated kinase domains that have provided opportunities to drive selectivity through structure-based avenues. The promise of isoform selective inhibitors and the rationale for their development are discussed in the broader context of the PKC inhibitor arsenal.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1879-0410
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
268-79
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Protein kinase C intervention: the state of play.
pubmed:affiliation
Discovery Laboratory, Cancer Research Technology Limited, Wolfson Institute for Biomedical Research, London, UK.
pubmed:publicationType
Journal Article, Review