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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2009-3-9
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pubmed:abstractText |
A novel iodine-catalyzed one-pot synthesis of symmetrically and asymmetrically substituted 3,6-diphenyl-[1,2,4,5]tetraoxanes is described. The synthetic protocol is general with substituted benzaldehydes and proceeds well under acidic conditions. Total 17 tetraoxanes have been prepared during this study and some of these compounds exhibit promising antimalarial activity. None of the compounds shows any toxicity against vero cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1464-3405
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1675-7
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pubmed:meshHeading |
pubmed-meshheading:19231182-Animals,
pubmed-meshheading:19231182-Antimalarials,
pubmed-meshheading:19231182-Artemisinins,
pubmed-meshheading:19231182-Cercopithecus aethiops,
pubmed-meshheading:19231182-Chemistry, Organic,
pubmed-meshheading:19231182-Chemistry, Pharmaceutical,
pubmed-meshheading:19231182-Drug Design,
pubmed-meshheading:19231182-Inhibitory Concentration 50,
pubmed-meshheading:19231182-Iodine,
pubmed-meshheading:19231182-Malaria, Falciparum,
pubmed-meshheading:19231182-Models, Chemical,
pubmed-meshheading:19231182-Molecular Structure,
pubmed-meshheading:19231182-Plasmodium falciparum,
pubmed-meshheading:19231182-Tetraoxanes,
pubmed-meshheading:19231182-Vero Cells
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pubmed:year |
2009
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pubmed:articleTitle |
Iodine-catalyzed one-pot synthesis and antimalarial activity evaluation of symmetrically and asymmetrically substituted 3,6-diphenyl[1,2,4,5]tetraoxanes.
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pubmed:affiliation |
Department of Chemistry, University of Delhi, Delhi 110 007, India.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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