Linked Life Data

19231155

Source:http://linkedlifedata.com/resource/pubmed/id/19231155

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2009-4-14
pubmed:abstractText
Inhibins are dimeric glycoproteins, composed of an alpha-subunit (inhibin-alpha) and one of two possible beta-subunits (betaA or betaB), with substantial roles in human reproduction and in endocrine-responsive tumours. The aims of this study were to determine the distribution of inhibin-alpha, -betaA and -betaB subunits in malignant human endometrial tissue and the assessment of an association with specific clinicopathologic tumour features and clinical outcome. A series of 302 endometrial cancer tissue samples were immunohistochemically analysed with monoclonal antibodies against inhibin subunits. The inhibin-alpha subunit showed a significant association with histological grading, surgical staging, lymph node status and diabetes in patients with endometrial cancer. Interestingly, loss of inhibin-alpha expression resulted in a poorer survival of endometrial cancer patients. Additionally, survival analysis demonstrated that inhibin-alpha immunoreactivity was an independent prognostic factor for progression-free survival, cause-specific survival as well as for overall survival. In contrast, although inhibin-betaA- and -betaB subunits showed a significant association between endometrial histological subtypes and histological grading, both subunits were not found to be associated with survival in endometrial cancer patients. Therefore, inhibin-alpha immunostaining might be used as a simple and efficient marker to identify high-risk patients leading to the selection of patients for an aggressive adjuvant therapy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1879-0852
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1304-14
pubmed:meshHeading
pubmed-meshheading:19231155-Adult, pubmed-meshheading:19231155-Age Factors, pubmed-meshheading:19231155-Aged, pubmed-meshheading:19231155-Aged, 80 and over, pubmed-meshheading:19231155-Carcinoma, pubmed-meshheading:19231155-Diabetes Mellitus, pubmed-meshheading:19231155-Disease-Free Survival, pubmed-meshheading:19231155-Endometrial Neoplasms, pubmed-meshheading:19231155-Female, pubmed-meshheading:19231155-Humans, pubmed-meshheading:19231155-Immunohistochemistry, pubmed-meshheading:19231155-Inhibin-beta Subunits, pubmed-meshheading:19231155-Inhibins, pubmed-meshheading:19231155-Lymphatic Metastasis, pubmed-meshheading:19231155-Middle Aged, pubmed-meshheading:19231155-Neoplasm Staging, pubmed-meshheading:19231155-Prognosis, pubmed-meshheading:19231155-Proportional Hazards Models, pubmed-meshheading:19231155-Survival Analysis, pubmed-meshheading:19231155-Tumor Markers, Biological
pubmed:year
2009
pubmed:articleTitle
Inhibin-alpha subunit is an independent prognostic parameter in human endometrial carcinomas: analysis of inhibin/activin-alpha, -betaA and -betaB subunits in 302 cases.
pubmed:affiliation
1st Department of Obstetrics and Gynaecology, Ludwig-Maximilians-University Munich, Maistrasse 11, 80337 Munich, Bavaria, Germany. ioannis.mylonas@med.uni-muenchen.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't