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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2009-4-23
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pubmed:abstractText |
Resistance to high-dose loop diuretics can be overcome either by co-administration with thiazides or by treatment with medium-dose loop diuretics combined with thiazides. Combination therapy has been proven to be superior to high-dose loop diuretic monotherapy for cardiac and renal edema. However, such a strongly efficacious short-term regimen is often complicated by undesired effects, including circulatory collapse and electrolyte disturbances. The question of whether the loop diuretic/thiazide combinations are efficacious and safe when conventional doses are combined has not yet been answered.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1432-1041
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
65
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
465-72
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pubmed:meshHeading |
pubmed-meshheading:19229529-Adult,
pubmed-meshheading:19229529-Diuretics,
pubmed-meshheading:19229529-Dose-Response Relationship, Drug,
pubmed-meshheading:19229529-Drug Combinations,
pubmed-meshheading:19229529-Female,
pubmed-meshheading:19229529-Humans,
pubmed-meshheading:19229529-Hydrochlorothiazide,
pubmed-meshheading:19229529-Magnesium,
pubmed-meshheading:19229529-Male,
pubmed-meshheading:19229529-Middle Aged,
pubmed-meshheading:19229529-Natriuresis,
pubmed-meshheading:19229529-Potassium,
pubmed-meshheading:19229529-Sulfonamides,
pubmed-meshheading:19229529-Thiazides
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pubmed:year |
2009
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pubmed:articleTitle |
Torasemide significantly reduces thiazide-induced potassium and magnesium loss despite supra-additive natriuresis.
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pubmed:affiliation |
Department of Medicine 1, St. Bernward-Krankenhaus, Hildesheim 31134, Germany. heinrich.knauf@t-online.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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