19228973

Source:http://linkedlifedata.com/resource/pubmed/id/19228973

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0042817, umls-concept:C1561605, umls-concept:C1561606
pubmed:issue	7
pubmed:dateCreated	2009-2-20
pubmed:abstractText	We investigated the key neurodevelopmental factors that determine cortical thickness, namely synaptogenesis and regression, by analyzing the thickness of the visual cortex in humans with early- and late-onset blindness. The bilateral visual cortices of the early blind were significantly thicker than those of the late blind and the sighted controls, but the latter two groups did not differ significantly. This suggests reduced "pruning" of synapses in the visual cortex, which may be due to a lack of visual experience during a critical developmental period. These findings support the hypothesis that sensory experience is necessary for an appropriate regression and remodeling of neuronal processes and that synaptic regression might be a major determinant of macroscopic anatomical features like cortical thickness.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8102140
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Feb
pubmed:issn	1529-2401
pubmed:author	pubmed-author:JiangJiefengJ, pubmed-author:JiangTianziT, pubmed-author:LiKunchengK, pubmed-author:LiuYongY, pubmed-author:MeeSS, pubmed-author:ShiFengF, pubmed-author:YuChunshuiC, pubmed-author:ZakP BPB, pubmed-author:ZhuWanlinW
pubmed:issnType	Electronic
pubmed:day	18
pubmed:volume	29
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	2205-11
pubmed:meshHeading	pubmed-meshheading:19228973-Adult, pubmed-meshheading:19228973-Age Factors, pubmed-meshheading:19228973-Age of Onset, pubmed-meshheading:19228973-Blindness, pubmed-meshheading:19228973-Brain Mapping, pubmed-meshheading:19228973-Cell Differentiation, pubmed-meshheading:19228973-Dendritic Spines, pubmed-meshheading:19228973-Female, pubmed-meshheading:19228973-Humans, pubmed-meshheading:19228973-Magnetic Resonance Imaging, pubmed-meshheading:19228973-Male, pubmed-meshheading:19228973-Neuronal Plasticity, pubmed-meshheading:19228973-Presynaptic Terminals, pubmed-meshheading:19228973-Sensory Deprivation, pubmed-meshheading:19228973-Synapses, pubmed-meshheading:19228973-Time Factors, pubmed-meshheading:19228973-Visual Cortex, pubmed-meshheading:19228973-Visual Pathways, pubmed-meshheading:19228973-Young Adult
pubmed:year	2009
pubmed:articleTitle	Thick visual cortex in the early blind.
pubmed:affiliation	LIAMA Center for Computational Medicine, National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't