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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2009-4-9
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pubmed:abstractText |
Although studies of Ames and Snell dwarf mice have suggested possible important roles of the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis in aging and age-related diseases, the results cannot rule out the possibility of other hormonal changes playing an important role in the life extension exhibited by these dwarf mice. Therefore, growth hormone receptor/binding protein (GHR/BP) knockout (KO) mice would be valuable animals to directly assess the roles of somatotropic axis in aging and age-related diseases because the primary hormonal change is due to GH/IGF-1 deficiency. Our pathological findings showed GHR/BP KO mice to have a lower incidence and delayed occurrence of fatal neoplastic lesions compared with their wild-type littermates. These changes of fatal neoplasms are similar to the effects observed with calorie restriction and therefore could possibly be a major contributing factor to the extended life span observed in the GHR/BP KO mice.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19228785-10067829,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19228785-10203270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19228785-10342852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19228785-10462163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19228785-10875265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19228785-10937058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19228785-10995803,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19228785-11371619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19228785-11487592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19228785-12147369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19228785-12359510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19228785-12663691,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19228785-14173795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19228785-1427647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19228785-15699523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19228785-16424282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19228785-1765417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19228785-1872127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19228785-3132856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19228785-4056322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19228785-7617139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19228785-8187095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19228785-8391647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19228785-8423678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19228785-8871629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19228785-8900272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19228785-8934515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19228785-9371826,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19228785-9814605
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1758-535X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
64
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
522-9
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pubmed:dateRevised |
2010-9-22
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pubmed:meshHeading |
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pubmed:year |
2009
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pubmed:articleTitle |
Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice.
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pubmed:affiliation |
Barshop Institute for Longevity and Aging Studies, San Antonio, TX 78245-3207, USA. ikeno@uthscsa.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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