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rdf:type |
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lifeskim:mentions |
umls-concept:C0015576,
umls-concept:C0033684,
umls-concept:C0036667,
umls-concept:C0086418,
umls-concept:C0149925,
umls-concept:C0164786,
umls-concept:C0312418,
umls-concept:C0334227,
umls-concept:C0376515,
umls-concept:C0812228,
umls-concept:C0962969,
umls-concept:C1704259,
umls-concept:C1705987,
umls-concept:C1879547
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pubmed:issue |
4
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pubmed:dateCreated |
2009-2-20
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pubmed:abstractText |
The Akt/mammalian target of rapamycin (mTOR) pathway is frequently activated in human cancers and plays an important role in small cell lung cancer (SCLC) biology. We investigated the potential of targeting mTOR signaling as a novel antitumor approach in SCLC.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/CDKN1A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/Etoposide,
http://linkedlifedata.com/resource/pubmed/chemical/MTOR protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/Sirolimus,
http://linkedlifedata.com/resource/pubmed/chemical/Stem Cell Factor,
http://linkedlifedata.com/resource/pubmed/chemical/TOR Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/everolimus,
http://linkedlifedata.com/resource/pubmed/chemical/mTOR protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/temsirolimus
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1078-0432
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pubmed:author |
pubmed-author:ArcaroAlexandreA,
pubmed-author:DhillonTonyT,
pubmed-author:LaneHeidi AHA,
pubmed-author:LemoineNicholas RNR,
pubmed-author:MarinovMarinM,
pubmed-author:MauriFrancesco AFA,
pubmed-author:PardoOlivier EOE,
pubmed-author:SecklMichael JMJ,
pubmed-author:TanLiwen TerenceLT,
pubmed-author:Zangemeister-WittkeUweU,
pubmed-author:ZiogasAlgirdasA
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1277-87
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:19228731-Animals,
pubmed-meshheading:19228731-Antineoplastic Agents,
pubmed-meshheading:19228731-Carcinoma, Small Cell,
pubmed-meshheading:19228731-Cell Line, Tumor,
pubmed-meshheading:19228731-Cyclin-Dependent Kinase Inhibitor p21,
pubmed-meshheading:19228731-Drug Resistance, Neoplasm,
pubmed-meshheading:19228731-Etoposide,
pubmed-meshheading:19228731-Humans,
pubmed-meshheading:19228731-Lung Neoplasms,
pubmed-meshheading:19228731-Mice,
pubmed-meshheading:19228731-Protein Kinases,
pubmed-meshheading:19228731-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:19228731-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:19228731-Signal Transduction,
pubmed-meshheading:19228731-Sirolimus,
pubmed-meshheading:19228731-Stem Cell Factor,
pubmed-meshheading:19228731-TOR Serine-Threonine Kinases
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pubmed:year |
2009
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pubmed:articleTitle |
AKT/mTOR pathway activation and BCL-2 family proteins modulate the sensitivity of human small cell lung cancer cells to RAD001.
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pubmed:affiliation |
Department of Oncology, University Children's Hospital Zurich, Zurich, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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