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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2009-3-3
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pubmed:abstractText |
Nerve injury-triggered hyperexcitability in primary sensory neurons is considered a major source of chronic neuropathic pain. The hyperexcitability, in turn, is thought to be related to transcriptional switching in afferent cell somata. Analysis using expression microarrays has revealed that many genes are regulated in the dorsal root ganglion (DRG) following axotomy. But which contribute to pain phenotype versus other nerve injury-evoked processes such as nerve regeneration? Using the L5 spinal nerve ligation model of neuropathy we examined differential changes in gene expression in the L5 (and L4) DRGs in five mouse strains with contrasting susceptibility to neuropathic pain. We sought genes for which the degree of regulation correlates with strain-specific pain phenotype.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1744-8069
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pubmed:author |
pubmed-author:DarvasiArielA,
pubmed-author:DevorMarshallM,
pubmed-author:Ding-PfennigdorffDanpingD,
pubmed-author:FriedKajK,
pubmed-author:GebauerMathiasM,
pubmed-author:JordanSuzanaS,
pubmed-author:Metz-WeidmannChristianeC,
pubmed-author:PerssonAnna-KarinAK,
pubmed-author:SchneiderHans-ChristophHC,
pubmed-author:SchulteAnke MAM,
pubmed-author:ThunJonasJ,
pubmed-author:Wiesenfeld-HallinZsuzsannaZ,
pubmed-author:XuXiao-JunXJ
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:19228393-Animals,
pubmed-meshheading:19228393-Ganglia, Spinal,
pubmed-meshheading:19228393-Gene Expression Profiling,
pubmed-meshheading:19228393-Gene Expression Regulation,
pubmed-meshheading:19228393-Mice,
pubmed-meshheading:19228393-Neuralgia,
pubmed-meshheading:19228393-Neuropeptides,
pubmed-meshheading:19228393-RNA, Messenger,
pubmed-meshheading:19228393-Sodium Channels,
pubmed-meshheading:19228393-Species Specificity,
pubmed-meshheading:19228393-TRPM Cation Channels
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pubmed:year |
2009
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pubmed:articleTitle |
Correlational analysis for identifying genes whose regulation contributes to chronic neuropathic pain.
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pubmed:affiliation |
Center for Oral Biology, Novum, Karolinska Institutet, S-141 04 Huddinge, Sweden. Anna-Karin.M.Persson@ki.se
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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