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pubmed:abstractText |
Protein translocation across the membrane of the Endoplasmic Reticulum (ER) is the first step in the biogenesis of secretory and membrane proteins. Proteins enter the ER by the Sec61 translocon, a proteinaceous channel composed of three subunits, alpha, beta and gamma. While it is known that Sec61alpha forms the actual channel, the function of the other two subunits remains to be characterized.
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