Linked Life Data

19225048

Source:http://linkedlifedata.com/resource/pubmed/id/19225048

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2009-4-27
pubmed:abstractText
TNF-alpha and NF-kappaB play important roles in the development of inflammation in chronic renal failure (CRF). In hepatic cells, curcumin is shown to antagonize TNF-alpha-elicited NF-kappaB activation. In this study, we hypothesized that if inflammation plays a key role in renal failure then curcumin should be effective in improving CRF. The effectiveness of curcumin was compared with enalapril, a compound known to ameliorate human and experimental CRF. Investigation was conducted in Sprague-Dawley rats where CRF was induced by 5/6 nephrectomy (Nx). The Nx animals were divided into untreated (Nx), curcumin-treated (curcumin), and enalapril-treated (enalapril) groups. Sham-operated animals served as a control. Renal dysfunction in the Nx group, as evidenced by elevated blood urea nitrogen, plasma creatinine, proteinuria, segmental sclerosis, and tubular dilatation, was significantly reduced by curcumin and enalapril treatment. However, only enalapril significantly improved blood pressure. Compared with the control, the Nx animals had significantly higher plasma and kidney TNF-alpha, which was associated with NF-kappaB activation and macrophage infiltration in the kidney. These changes were effectively antagonized by curcumin and enalapril treatment. The decline in the anti-inflammatory peroxisome proliferator-activated receptor gamma (PPARgamma) seen in Nx animals was also counteracted by curcumin and enalapril. Studies in mesangial cells were carried out to further establish that the anti-inflammatory effect of curcumin in vivo was mediated essentially by antagonizing TNF-alpha. Curcumin dose dependently antagonized the TNF-alpha-mediated decrease in PPARgamma and blocked transactivation of NF-kappaB and repression of PPARgamma, indicating that the anti-inflamatory property of curcumin may be responsible for alleviating CRF in Nx animals.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1931-857X
pubmed:author
pubmed:issnType
Print
pubmed:volume
296
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
F1146-57
pubmed:dateRevised
2011-4-28
pubmed:meshHeading
pubmed-meshheading:19225048-Angiotensin-Converting Enzyme Inhibitors, pubmed-meshheading:19225048-Animals, pubmed-meshheading:19225048-Anti-Inflammatory Agents, Non-Steroidal, pubmed-meshheading:19225048-Blood Pressure, pubmed-meshheading:19225048-Blood Urea Nitrogen, pubmed-meshheading:19225048-Cells, Cultured, pubmed-meshheading:19225048-Creatinine, pubmed-meshheading:19225048-Curcumin, pubmed-meshheading:19225048-Disease Models, Animal, pubmed-meshheading:19225048-Enalapril, pubmed-meshheading:19225048-Hypertension, Renal, pubmed-meshheading:19225048-Kidney Failure, Chronic, pubmed-meshheading:19225048-Macrophages, pubmed-meshheading:19225048-Mesangial Cells, pubmed-meshheading:19225048-NF-kappa B, pubmed-meshheading:19225048-Nephrectomy, pubmed-meshheading:19225048-Nephritis, pubmed-meshheading:19225048-PPAR gamma, pubmed-meshheading:19225048-Proteinuria, pubmed-meshheading:19225048-Rats, pubmed-meshheading:19225048-Rats, Sprague-Dawley, pubmed-meshheading:19225048-Transfection, pubmed-meshheading:19225048-Tumor Necrosis Factor-alpha
pubmed:year
2009
pubmed:articleTitle
Curcumin ameliorates renal failure in 5/6 nephrectomized rats: role of inflammation.
pubmed:affiliation
Department of Internal Medicine/Nephrology, Sanger Hall, Rm. 8-059, Virginia Commonwealth Univ., 1101 E. Marshall St., Richmond, VA 23298, USA. ssghosh@hsc.vcu.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't