Acute phase serum amyloid A (A-SAA) is secreted by hepatocytes in response to injury and is regulated by proinflammatory cytokines. In obese humans, adipocytes are also a major contributor to circulating A-SAA levels.
Institut National de la Santé et de la Recherche Médicale, U872 team7, Nutriomique, Cordelier Research Center, Paris 75006, France. christine.poitou-bernert@psl.aphp.fr