Linked Life Data

19222470

Source:http://linkedlifedata.com/resource/pubmed/id/19222470

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-6-15
pubmed:abstractText
Prior case-control studies reported that levels of the soluble form of the endothelial protein C receptor (sEPCR) were strongly controlled by the PROCR 6963A/G polymorphism and higher levels were a risk factor for venous thromboembolism (VTE). We sought to prospectively examine the association of sEPCR and the 6963A/G polymorphism with the incidence of VTE. The Longitudinal Investigation of Thromboembolism Etiology (LITE) pooled data from the Cardiovascular Health Study (CHS) and the Atherosclerosis Risk in Communities (ARIC) Study on men and women aged > or =45 years. A nested case-control study of 458 incident VTE and 1038 controls was performed. sEPCR levels were distributed trimodally according to 6963A/G polymorphism. Adjusting for age, sex and race, there was no overall association between sEPCR level and VTE: odds ratio (OR) [95% confidence interval] for highest versus lowest quartile = 1.17[0.86-1.59]. However, higher sEPCR was associated with VTE in non-whites (OR = 1.84[1.05-3.22]) and women (OR = 1.51[1.01-2.26]). The 6963A/G polymorphism was not associated with VTE risk (OR = 0.93[0.70-1.25]). In conclusion, sEPCR levels and the PROCR 6963A/G polymorphism were not associated overall with increased risk of VTE.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19222470-11929758, http://linkedlifedata.com/resource/pubmed/commentcorrection/19222470-12020191, http://linkedlifedata.com/resource/pubmed/commentcorrection/19222470-12447958, http://linkedlifedata.com/resource/pubmed/commentcorrection/19222470-12505113, http://linkedlifedata.com/resource/pubmed/commentcorrection/19222470-14576048, http://linkedlifedata.com/resource/pubmed/commentcorrection/19222470-15116250, http://linkedlifedata.com/resource/pubmed/commentcorrection/19222470-15210384, http://linkedlifedata.com/resource/pubmed/commentcorrection/19222470-15304035, http://linkedlifedata.com/resource/pubmed/commentcorrection/19222470-15943976, http://linkedlifedata.com/resource/pubmed/commentcorrection/19222470-1669507, http://linkedlifedata.com/resource/pubmed/commentcorrection/19222470-16888445, http://linkedlifedata.com/resource/pubmed/commentcorrection/19222470-17425663, http://linkedlifedata.com/resource/pubmed/commentcorrection/19222470-17723119, http://linkedlifedata.com/resource/pubmed/commentcorrection/19222470-2646917, http://linkedlifedata.com/resource/pubmed/commentcorrection/19222470-7740458, http://linkedlifedata.com/resource/pubmed/commentcorrection/19222470-7874780, http://linkedlifedata.com/resource/pubmed/commentcorrection/19222470-8916933, http://linkedlifedata.com/resource/pubmed/commentcorrection/19222470-9286936
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1365-2141
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
145
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
221-6
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Lack of association of soluble endothelial protein C receptor and PROCR 6936A/G polymorphism with the risk of venous thromboembolism in a prospective study.
pubmed:affiliation
Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55454, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural