Linked Life Data

19222120

Source:http://linkedlifedata.com/resource/pubmed/id/19222120

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2009-2-17
pubmed:abstractText
Hepatocellular carcinoma is a type of tumor highly resistant to available chemotherapeutic agents. The treatment of hepatocellular carcinoma remains a challenge that needs new approaches in the future. In a previous study, we demonstrated that the chloroform fraction (CHCl(3)-F) from Z. jujuba has anticancer activity in human liver cancer cells (HepG2), and that combining CHCl(3)-F with green tea extracts (GTE) results in enhanced effects of anticancer activity in the cells. To further understand the mechanism of the anticancer activity of combining CHCl(3)-F and GTE in HepG2 cells, we investigated whether the addition of a mixture of CHCl(3)-F and GTE would affect the expression of APRIL (a proliferation-inducing ligand), which was expressed in HepG2 cells from 4 hours of incubation in vitro. We have shown that CHCl(3)-F and GTE enhanced anti-cancer activity by reducing the expression of APRIL. We speculate that the CHCl(3)-F and GTE mixture might provide a lead to a new drug design to treat hepatocellular carcinoma in the future.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0192-415X
pubmed:author
pubmed:issnType
Print
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
169-79
pubmed:meshHeading
pubmed-meshheading:19222120-Animals, pubmed-meshheading:19222120-Antineoplastic Agents, Phytogenic, pubmed-meshheading:19222120-Antineoplastic Combined Chemotherapy Protocols, pubmed-meshheading:19222120-Camellia sinensis, pubmed-meshheading:19222120-Carcinoma, Hepatocellular, pubmed-meshheading:19222120-Cell Cycle, pubmed-meshheading:19222120-Cell Line, Tumor, pubmed-meshheading:19222120-Cell Survival, pubmed-meshheading:19222120-Gene Expression, pubmed-meshheading:19222120-Humans, pubmed-meshheading:19222120-Liver Neoplasms, pubmed-meshheading:19222120-Phytotherapy, pubmed-meshheading:19222120-Plant Extracts, pubmed-meshheading:19222120-Rats, pubmed-meshheading:19222120-Tea, pubmed-meshheading:19222120-Tumor Necrosis Factor Ligand Superfamily Member 13, pubmed-meshheading:19222120-Ziziphus
pubmed:year
2009
pubmed:articleTitle
Combination of Zizyphus jujuba and green tea extracts exerts excellent cytotoxic activity in HepG2 cells via reducing the expression of APRIL.
pubmed:affiliation
Department of Food and Human Health Sciences, Graduate School of Human Life Science, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't