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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0021853,
umls-concept:C0027651,
umls-concept:C0185117,
umls-concept:C0205307,
umls-concept:C0255194,
umls-concept:C0381451,
umls-concept:C0475264,
umls-concept:C0555952,
umls-concept:C0851285,
umls-concept:C1334141,
umls-concept:C2911684
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pubmed:issue |
9
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pubmed:dateCreated |
2009-8-12
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pubmed:abstractText |
Self-renewal and differentiation of intestinal epithelium is a tightly regulated process, whose perturbations are implicated in human colorectal tumourigenesis. The insulin/insulin-like growth factor (IGF) signalling pathway may play an important role in intestinal epithelium homeostasis. Insulin receptor substrate 2 (IRS2) is a poorly characterised component in this pathway.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1468-3288
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pubmed:author |
pubmed-author:DulucII,
pubmed-author:EspositoD LDL,
pubmed-author:FreundJ-NJN,
pubmed-author:Mariani-CostantiniRR,
pubmed-author:ModicaSS,
pubmed-author:MorganoAA,
pubmed-author:MoschettaAA,
pubmed-author:PalascianoGG,
pubmed-author:PetruzzelliMM,
pubmed-author:SalvatoreLL,
pubmed-author:ValanzanoRR,
pubmed-author:VanierM-TMT
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pubmed:issnType |
Electronic
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pubmed:volume |
58
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1250-9
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pubmed:meshHeading |
pubmed-meshheading:19221108-Animals,
pubmed-meshheading:19221108-Cell Differentiation,
pubmed-meshheading:19221108-Cell Line, Tumor,
pubmed-meshheading:19221108-Colon,
pubmed-meshheading:19221108-Colorectal Neoplasms,
pubmed-meshheading:19221108-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:19221108-HT29 Cells,
pubmed-meshheading:19221108-Homeodomain Proteins,
pubmed-meshheading:19221108-Humans,
pubmed-meshheading:19221108-Ileum,
pubmed-meshheading:19221108-Immunohistochemistry,
pubmed-meshheading:19221108-Insulin Receptor Substrate Proteins,
pubmed-meshheading:19221108-Insulin-Like Growth Factor I,
pubmed-meshheading:19221108-Intestinal Mucosa,
pubmed-meshheading:19221108-Male,
pubmed-meshheading:19221108-Mice,
pubmed-meshheading:19221108-Multiple Endocrine Neoplasia,
pubmed-meshheading:19221108-Promoter Regions, Genetic,
pubmed-meshheading:19221108-Protein Binding,
pubmed-meshheading:19221108-RNA, Messenger,
pubmed-meshheading:19221108-Reverse Transcriptase Polymerase Chain Reaction
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pubmed:year |
2009
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pubmed:articleTitle |
Expression and localisation of insulin receptor substrate 2 in normal intestine and colorectal tumours. Regulation by intestine-specific transcription factor CDX2.
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pubmed:affiliation |
University of Bari, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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