Source:http://linkedlifedata.com/resource/pubmed/id/19221099
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2010-6-15
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| pubmed:abstractText |
Our aim was to investigate the CD40-CD40 ligand system in preeclamptic women. We also studied CD62P and platelet-monocyte aggregates, which have been closely linked to the CD40-CD40L system. Platelet expression of CD40L and CD62P and expression of CD40 on monocytes and platelet-monocyte aggregates were determined by flow cytometry in whole blood from 23 preeclamptic women, 23 normotensive pregnant women, and 23 nonpregnant women. The preeclamptic women showed a significant increase in CD40L and CD62P on platelets and in CD40 on monocytes when compared with normotensive pregnant women and nonpregnant women (all P < .001). There was a significant increase in platelet-monocyte aggregates in preeclamptic women (P < .001) and normotensive pregnant women (P = .003) compared with nonpregnant women. Preeclampsia is associated with activation of the CD40-CD40L system. The activation of this system may contribute to the development or maintenance of the proinflammatory and prothrombotic milieu found in preeclampsia.
|
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
1938-2723
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
16
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
306-12
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| pubmed:meshHeading |
pubmed-meshheading:19221099-Adult,
pubmed-meshheading:19221099-Antigens, CD40,
pubmed-meshheading:19221099-Blood Platelets,
pubmed-meshheading:19221099-CD40 Ligand,
pubmed-meshheading:19221099-Case-Control Studies,
pubmed-meshheading:19221099-Cell Aggregation,
pubmed-meshheading:19221099-Female,
pubmed-meshheading:19221099-Flow Cytometry,
pubmed-meshheading:19221099-HELLP Syndrome,
pubmed-meshheading:19221099-Humans,
pubmed-meshheading:19221099-Inflammation,
pubmed-meshheading:19221099-Monocytes,
pubmed-meshheading:19221099-P-Selectin,
pubmed-meshheading:19221099-Platelet Activation,
pubmed-meshheading:19221099-Pre-Eclampsia,
pubmed-meshheading:19221099-Pregnancy,
pubmed-meshheading:19221099-Pregnancy Complications,
pubmed-meshheading:19221099-Thrombophilia,
pubmed-meshheading:19221099-Young Adult
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
Flow cytometric investigation of CD40-CD40 ligand system in preeclampsia and normal pregnancy.
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| pubmed:affiliation |
Immunology Laboratory, University Hospital, Pleven, Bulgaria. Bulgarialukanovtz@abv.bg
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| pubmed:publicationType |
Journal Article
|