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pubmed-article:19220731pubmed:abstractTextHemophilia A is a congenital bleeding disorder caused by a deficiency of coagulation factor VIII. Approximately 30% of hemophilia A patients develop inhibitors against FVIII following replacement therapy. We have reported that neonatal exposure of FVIII antigen can induce antigen-specific immune tolerance by interferon-gamma (IFN-gamma)-dependent T-cell anergy in hemophilia A mice.lld:pubmed
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pubmed-article:19220731pubmed:articleTitleInduction of factor VIII-specific unresponsiveness by intrathymic factor VIII injection in murine hemophilia A.lld:pubmed
pubmed-article:19220731pubmed:affiliationResearch Division of Cell and Molecular Medicine, Centre for Molecular Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan. madochan@jichi.ac.jplld:pubmed
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