Source:http://linkedlifedata.com/resource/pubmed/id/19220731
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2009-5-12
|
| pubmed:abstractText |
Hemophilia A is a congenital bleeding disorder caused by a deficiency of coagulation factor VIII. Approximately 30% of hemophilia A patients develop inhibitors against FVIII following replacement therapy. We have reported that neonatal exposure of FVIII antigen can induce antigen-specific immune tolerance by interferon-gamma (IFN-gamma)-dependent T-cell anergy in hemophilia A mice.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
1538-7836
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
7
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
811-24
|
| pubmed:meshHeading |
pubmed-meshheading:19220731-Animals,
pubmed-meshheading:19220731-Autoantibodies,
pubmed-meshheading:19220731-CD4-Positive T-Lymphocytes,
pubmed-meshheading:19220731-Cell Proliferation,
pubmed-meshheading:19220731-Factor VIII,
pubmed-meshheading:19220731-Flow Cytometry,
pubmed-meshheading:19220731-Hemophilia A,
pubmed-meshheading:19220731-Mice,
pubmed-meshheading:19220731-Thymus Gland
|
| pubmed:year |
2009
|
| pubmed:articleTitle |
Induction of factor VIII-specific unresponsiveness by intrathymic factor VIII injection in murine hemophilia A.
|
| pubmed:affiliation |
Research Division of Cell and Molecular Medicine, Centre for Molecular Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan. madochan@jichi.ac.jp
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|