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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2009-2-16
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pubmed:abstractText |
The present study investigated the efficacy of nefazodone and bupropion-sustained release for treating cannabis dependence. A double-blind, placebo-controlled, piggy back design was employed to assess if nefazodone and bupropion-sustained release increased the probability of abstinence from cannabis and reduced the severity of cannabis dependence and cannabis withdrawal symptoms during a 13-week outpatient treatment program. One-hundred and six participants (Mean = 32 years; females n = 25) were randomized to one of three medication conditions (nefazodone, bupropion-sustained release, or placebo) and participated in a weekly, individually based coping skills therapy program. Results indicated an increased probability of achieving abstinence over the course of treatment and a decrease in the severity of cannabis dependence and the withdrawal symptom of irritability. There were no significant effects demonstrated for nefazodone and bupropion-sustained release on cannabis use or cannabis withdrawal symptoms. The results indicate nefazodone and bupropion-sustained release may have limited efficacy in treating cannabis dependence.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19219666-10090646,
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1521-0391
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
53-64
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:19219666-Adult,
pubmed-meshheading:19219666-Antidepressive Agents, Second-Generation,
pubmed-meshheading:19219666-Bupropion,
pubmed-meshheading:19219666-Delayed-Action Preparations,
pubmed-meshheading:19219666-Double-Blind Method,
pubmed-meshheading:19219666-Female,
pubmed-meshheading:19219666-Humans,
pubmed-meshheading:19219666-Male,
pubmed-meshheading:19219666-Marijuana Abuse,
pubmed-meshheading:19219666-Outcome Assessment (Health Care),
pubmed-meshheading:19219666-Placebos,
pubmed-meshheading:19219666-Severity of Illness Index,
pubmed-meshheading:19219666-Substance Withdrawal Syndrome,
pubmed-meshheading:19219666-Triazoles
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pubmed:articleTitle |
A preliminary trial: double-blind comparison of nefazodone, bupropion-SR, and placebo in the treatment of cannabis dependence.
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pubmed:affiliation |
Division on Substance Abuse, New York State Psychiatric Institute, New York, USA.
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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