Linked Life Data

1921921

Source:http://linkedlifedata.com/resource/pubmed/id/1921921

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1991-11-18
pubmed:abstractText
This report examines possible adverse effects on size and growth associated with subclinical prenatal and preschool age lead exposure in an urban cohort followed prospectively from birth through early childhood. Measurements of weight, stature (length), and head circumference were obtained at birth and during five subsequent in-home assessments. Prenatal lead exposure was assessed by cord (n = 185) and maternal (n = 162) blood lead levels at delivery. Preschool blood lead samples were obtained at ages six months (n = 151), two years (n = 165), three years (n = 165), and four years, ten months (n = 164). Multivariate longitudinal analyses incorporating adjustment for covariates revealed no statistically significant adverse effects of prenatal lead exposure on either neonatal size or on subsequent growth through age four years, ten months. Similarly, no statistically significant adverse effects were found between the preschool lead indices derived from blood collected at or after age two years and ensuing size measurements. We also found no evidence for an interaction between pre- and postnatal lead exposure. A marginal inverse association was exhibited between blood lead at six months and subsequent measures of head circumference. Limitations in the implications of this result in the context of many nonsignificant tests were discussed.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0892-0362
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
417-27
pubmed:dateRevised
2009-10-26
pubmed:meshHeading
pubmed:articleTitle
Prenatal and preschool age lead exposure: relationship with size.
pubmed:affiliation
Department of Psychiatry, Case Western Reserve University, Cleveland, OH 44106.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't