Linked Life Data

19215907

Source:http://linkedlifedata.com/resource/pubmed/id/19215907

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2009-2-13
pubmed:abstractText
Small ubiquitin-like modifiers (SUMOs) mediate a variety of cellular functions of protein targets mainly in the nucleus but in other cellular compartments as well, and thereby participate in maintaining cellular homeostasis. SUMO system plays important roles in transcriptional regulation, DNA damage responses, maintaining genome integrity, and signaling pathways. Thus, in some cases, loss of regulated control on SUMOylation/deSUMOylation processes causes a defect in maintaining homeostasis and hence gives a cue to cancer development and progression. Furthermore, recent studies have revealed that SUMO system is involved in cancer metastasis. In this review, we will summarize the possible role of SUMO system in cancer development, progression, and metastasis and discuss future directions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1937-6448
pubmed:author
pubmed:issnType
Print
pubmed:volume
273
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
265-311
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Small ubiquitin-like modifiers in cellular malignancy and metastasis.
pubmed:affiliation
Department of Biological Sciences, Research Center for Women's Disease, Sookmyung Women's University, Seoul, Korea.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't