Linked Life Data

19215771

Source:http://linkedlifedata.com/resource/pubmed/id/19215771

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2009-2-13
pubmed:abstractText
Instability is a fundamental property of mRNA that is necessary for the regulation of gene expression. In E. coli, the turnover of mRNA involves multiple, redundant pathways involving 3'-exoribonucleases, endoribonucleases, and a variety of other enzymes that modify RNA covalently or affect its conformation. Endoribonucleases are thought to initiate or accelerate the process of mRNA degradation. A major endoribonuclease in this process is RNase E, which is a key component of the degradative machinery amongst the Proteobacteria. RNase E is the central element in a multienzyme complex known as the RNA degradosome. Structural and functional data are converging on models for the mechanism of activation and regulation of RNase E and its paralog, RNase G. Here, we discuss current models for mRNA degradation in E. coli and we present current thinking on the structure and function of RNase E based on recent crystal structures of its catalytic core.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1877-1173
pubmed:author
pubmed:issnType
Print
pubmed:volume
85
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
91-135
pubmed:dateRevised
2011-6-15
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Endonucleolytic initiation of mRNA decay in Escherichia coli.
pubmed:affiliation
Laboratoire de Microbiologie et Génétique Moléculaires, CNRS et Université Paul Sabatier, 31062 Toulouse, France.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't