Linked Life Data

19214787

Source:http://linkedlifedata.com/resource/pubmed/id/19214787

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2010-1-22
pubmed:abstractText
Hoxc8 has multiple roles in normal skeletal development. In this paper, a MC3T3-E1 subclone 4 osteogenic cell differentiation model was used to examine expression of Hoxc8 at multiple stages of osteogenesis. We found that Hoxc8 expression levels do not change in the early stage but increase in the middle stage and decrease in the late stage of osteogenesis. A knockdown of Hoxc8 by small-interfering RNA transfection in C2C12 cells indicated that Hoxc8 is a negative regulator of osteogenesis. Similarly, expression of Hoxc8 in C2C12 cells decreases alkaline phosphatase levels induced by bone morphogenetic protein-2 (BMP-2). The results of this study showed that Hoxc8 is involved in BMP-2-induced osteogenesis, and osteoblast differentiation in vitro is negatively regulated by Hoxc8, suggesting that Hoxc8 regulation is essential for osteoblast differentiation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1559-0291
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
160
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
891-900
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
In vitro osteoblast differentiation is negatively regulated by Hoxc8.
pubmed:affiliation
Department of Anatomy, Embryology Lab, Brain Korea 21 Project for Medical Science, College of Medicine, Yonsei University, 134 Seodaemun-gu, Shinchon-dong, 120-752 Seoul, South Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't