rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5920
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pubmed:dateCreated |
2009-3-16
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pubmed:abstractText |
Vesicular secretion of neurotransmitter is essential for neuronal communication. Kiss-and-run is a mode of membrane fusion and retrieval without the full collapse of the vesicle into the plasma membrane and de novo regeneration. The importance of kiss-and-run during efficient neurotransmission has remained in doubt. We developed an approach for loading individual synaptic vesicles with single quantum dots. Their size and pH-dependent photoluminescence change allowed us to distinguish kiss-and-run from full-collapse fusion and to track single vesicles through multiple rounds of kiss-and-run and reuse, without perturbing vesicle cycling. Kiss-and-run dominated at the beginning of stimulus trains, reflecting the preference of vesicles with high release probability. Its incidence was increased by rapid firing, a response appropriate to shape the kinetics of neurotransmission during a wide range of firing patterns.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19213879-10783237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19213879-10811737,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19213879-9671304
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1095-9203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
13
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pubmed:volume |
323
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1448-53
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:19213879-Animals,
pubmed-meshheading:19213879-Cells, Cultured,
pubmed-meshheading:19213879-Electric Stimulation,
pubmed-meshheading:19213879-Hippocampus,
pubmed-meshheading:19213879-Hydrogen-Ion Concentration,
pubmed-meshheading:19213879-Ion Transport,
pubmed-meshheading:19213879-Luminescence,
pubmed-meshheading:19213879-Membrane Fusion,
pubmed-meshheading:19213879-Neurons,
pubmed-meshheading:19213879-Neurotransmitter Agents,
pubmed-meshheading:19213879-Presynaptic Terminals,
pubmed-meshheading:19213879-Quantum Dots,
pubmed-meshheading:19213879-Rats,
pubmed-meshheading:19213879-Rats, Sprague-Dawley,
pubmed-meshheading:19213879-Synaptic Membranes,
pubmed-meshheading:19213879-Synaptic Transmission,
pubmed-meshheading:19213879-Synaptic Vesicles
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pubmed:year |
2009
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pubmed:articleTitle |
The dynamic control of kiss-and-run and vesicular reuse probed with single nanoparticles.
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pubmed:affiliation |
Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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