| pubmed-article:19213872 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19213872 | lifeskim:mentions | umls-concept:C0024501 | lld:lifeskim |
| pubmed-article:19213872 | lifeskim:mentions | umls-concept:C0374711 | lld:lifeskim |
| pubmed-article:19213872 | lifeskim:mentions | umls-concept:C0105770 | lld:lifeskim |
| pubmed-article:19213872 | lifeskim:mentions | umls-concept:C0014609 | lld:lifeskim |
| pubmed-article:19213872 | lifeskim:mentions | umls-concept:C0006270 | lld:lifeskim |
| pubmed-article:19213872 | lifeskim:mentions | umls-concept:C0043240 | lld:lifeskim |
| pubmed-article:19213872 | lifeskim:mentions | umls-concept:C1705181 | lld:lifeskim |
| pubmed-article:19213872 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:19213872 | pubmed:dateCreated | 2009-10-21 | lld:pubmed |
| pubmed-article:19213872 | pubmed:abstractText | Signaling by Wnt/beta-catenin regulates self-renewal of tissue stem cells in the gut and, when activated in the embryonic bronchiolar epithelium, leads to stem cell expansion. We have used transgenic and cell type-specific knockout strategies to determine roles for beta-catenin-regulated gene expression in normal maintenance and repair of the bronchiolar epithelium. Analysis of TOPGal transgene activity detected beta-catenin signaling in the steady-state and repairing bronchiolar epithelium. However, the broad distribution and phenotype of signaling cells precluded establishment of a clear role for beta-catenin in the normal or repairing state. Necessity of beta-catenin signaling was tested through Cre-mediated deletion of Catnb exons 2-6 in airway epithelial cells. Functional knockout of beta-catenin had no impact on expression of Clara cell differentiation markers, mitotic index, or sensitivity of these cells to the Clara cell-specific toxicant, naphthalene. Repair of the naphthalene-injured airway proceeded with establishment of focal regions of beta-catenin-null epithelium. The size of regenerative epithelial units, mitotic index, and restoration of the ciliated cell population did not vary between wild-type and genetically modified mice. Thus, beta-catenin was not necessary for maintenance or efficient repair of the bronchiolar epithelium. | lld:pubmed |
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| pubmed-article:19213872 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19213872 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19213872 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19213872 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19213872 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19213872 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19213872 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19213872 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19213872 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:19213872 | pubmed:issn | 1535-4989 | lld:pubmed |
| pubmed-article:19213872 | pubmed:author | pubmed-author:GiangrecoAdam... | lld:pubmed |
| pubmed-article:19213872 | pubmed:author | pubmed-author:ReynoldsSusan... | lld:pubmed |
| pubmed-article:19213872 | pubmed:author | pubmed-author:StrippBarry... | lld:pubmed |
| pubmed-article:19213872 | pubmed:author | pubmed-author:ZemkeAnna CAC | lld:pubmed |
| pubmed-article:19213872 | pubmed:author | pubmed-author:BrockwayBrian... | lld:pubmed |
| pubmed-article:19213872 | pubmed:author | pubmed-author:TeisanuRoxana... | lld:pubmed |
| pubmed-article:19213872 | pubmed:author | pubmed-author:DrakeJeff AJA | lld:pubmed |
| pubmed-article:19213872 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19213872 | pubmed:volume | 41 | lld:pubmed |
| pubmed-article:19213872 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19213872 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19213872 | pubmed:pagination | 535-43 | lld:pubmed |
| pubmed-article:19213872 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:19213872 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19213872 | pubmed:articleTitle | beta-Catenin is not necessary for maintenance or repair of the bronchiolar epithelium. | lld:pubmed |
| pubmed-article:19213872 | pubmed:affiliation | Center for Lung Regeneration, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. | lld:pubmed |
| pubmed-article:19213872 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19213872 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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