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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2009-4-10
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pubmed:abstractText |
Progressive multifocal leukoencephalopathy (PML) is a frequently fatal disease caused by uncontrolled polyomavirus JC (JCV) in severely immunodeficient patients. We investigated the JCV-specific cellular and humoral immunity in the Swiss HIV Cohort Study. We identified PML cases (n = 29), as well as three matched controls per case (n = 87), with prospectively cryopreserved peripheral blood mononuclear cells and plasma at diagnosis. Nested controls were matched according to age, gender, CD4(+) T-cell count, and decline. Survivors (n = 18) were defined as being alive for >1 year after diagnosis. Using gamma interferon enzyme-linked immunospot assays, we found that JCV-specific T-cell responses were lower in nonsurvivors than in their matched controls (P = 0.08), which was highly significant for laboratory- and histologically confirmed PML cases (P = 0.004). No difference was found between PML survivors and controls or for cytomegalovirus-specific T-cell responses. PML survivors showed significant increases in JCV-specific T cells (P = 0.04) and immunoglobulin G (IgG) responses (P = 0.005). IgG responses in survivors were positively correlated with CD4(+) T-cell counts (P = 0.049) and negatively with human immunodeficiency virus RNA loads (P = 0.03). We conclude that PML nonsurvivors had selectively impaired JCV-specific T-cell responses compared to CD4(+) T-cell-matched controls and failed to mount JCV-specific antibody responses. JCV-specific T-cell and IgG responses may serve as prognostic markers for patients at risk.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19211737-10513646,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19211737-11357954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19211737-11517410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19211737-11751998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19211737-12210625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19211737-12626455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19211737-12684918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19211737-12709878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19211737-12824781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19211737-12824794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19211737-12858417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19211737-1310438,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19211737-15095223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19211737-15215217,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19211737-15816900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19211737-15947078,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19211737-15947079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19211737-15947080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19211737-16315252,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19211737-16687057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19211737-17229701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19211737-17359507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19211737-17434098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19211737-18410354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19211737-18541023,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19211737-18667930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19211737-18753934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19211737-3296901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19211737-7817627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19211737-9207375,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19211737-9677163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19211737-9749600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19211737-9858506
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1098-5514
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pubmed:author |
pubmed-author:BattegayManuelM,
pubmed-author:BernasconiEnosE,
pubmed-author:Du PasquierRenaud ARA,
pubmed-author:FuxChristoph ACA,
pubmed-author:GarzoniChristianC,
pubmed-author:HirschHans HHH,
pubmed-author:KhannaNinaN,
pubmed-author:MuellerNicolas JNJ,
pubmed-author:Swiss HIV Cohort Study,
pubmed-author:VernazzaPietroP,
pubmed-author:ViscidiRaphaelR,
pubmed-author:WolbersMarcelM
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pubmed:issnType |
Electronic
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4404-11
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pubmed:dateRevised |
2010-9-23
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pubmed:meshHeading |
pubmed-meshheading:19211737-Adult,
pubmed-meshheading:19211737-CD4-Positive T-Lymphocytes,
pubmed-meshheading:19211737-Cell Proliferation,
pubmed-meshheading:19211737-Cytomegalovirus,
pubmed-meshheading:19211737-Disease Progression,
pubmed-meshheading:19211737-Female,
pubmed-meshheading:19211737-HIV Infections,
pubmed-meshheading:19211737-HIV-1,
pubmed-meshheading:19211737-Humans,
pubmed-meshheading:19211737-JC Virus,
pubmed-meshheading:19211737-Leukoencephalopathy, Progressive Multifocal,
pubmed-meshheading:19211737-Male,
pubmed-meshheading:19211737-Middle Aged,
pubmed-meshheading:19211737-RNA, Viral,
pubmed-meshheading:19211737-Survival Rate
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pubmed:year |
2009
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pubmed:articleTitle |
JC virus-specific immune responses in human immunodeficiency virus type 1 patients with progressive multifocal leukoencephalopathy.
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pubmed:affiliation |
Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, CH-4031 Basel, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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