rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2009-2-12
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pubmed:abstractText |
Several influential studies of genotypic determinants of gene expression in humans have now been published based on various populations including HapMap cohorts. The magnitude of the analytic task (transcriptome vs. SNP-genome) is a hindrance to dissemination of efficient, thorough, and auditable inference methods for this project. We describe the structure and use of Bioconductor facilities for inference in genetics of gene expression, with simultaneous application to multiple HapMap cohorts. Tools distributed for this purpose are readily adapted for the structure and analysis of privately-generated data in expression genetics.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1793-5091
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
380-90
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19209716-Biometry,
pubmed-meshheading:19209716-Carrier Proteins,
pubmed-meshheading:19209716-Cohort Studies,
pubmed-meshheading:19209716-Databases, Genetic,
pubmed-meshheading:19209716-Forkhead Transcription Factors,
pubmed-meshheading:19209716-Gene Expression Profiling,
pubmed-meshheading:19209716-Genetics, Population,
pubmed-meshheading:19209716-HLA-DR Antigens,
pubmed-meshheading:19209716-HLA-DRB1 Chains,
pubmed-meshheading:19209716-Humans,
pubmed-meshheading:19209716-Polymorphism, Single Nucleotide,
pubmed-meshheading:19209716-Quantitative Trait Loci,
pubmed-meshheading:19209716-Regulatory Elements, Transcriptional,
pubmed-meshheading:19209716-Software,
pubmed-meshheading:19209716-Urotensins
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pubmed:year |
2009
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pubmed:articleTitle |
Interpreting genetics of gene expression: integrative architecture in Bioconductor.
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pubmed:affiliation |
Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Ave., Boston, MA 02115, USA. stvjc@channing.harvard.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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