Linked Life Data

19207979

Source:http://linkedlifedata.com/resource/pubmed/id/19207979

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2009-2-11
pubmed:abstractText
Early diagnosis of hepatocellular carcinoma (HCC) is feasible because HCC develops in the background of well-known, readily identifiable and potentially avoidable environmental risk factors. According to the American Association for the Study of the Liver Diseases and the European Association for the Study of the Liver, patients with cirrhosis and carriers of chronic viral hepatitis are the target of surveillance to be investigated with abdominal ultrasounds (US) every 6 or 12 months. The diagnostic confirmation of a > or =2 cm nodule in patients with cirrhosis detected during surveillance is possible with any imaging technique among second-generation contrast US, contrast computed tomography and gadolinium-contrast magnetic resonance imaging. HCC shows an early hyperenhanced arterial vascularization, followed by enhanced hypoattenuation (wash-out) in the late phase of imaging. In patients with a < or =2 cm nodule, two imaging techniques are required for the final diagnosis, which, however, have a relatively low diagnostic sensitivity (33%). Nodules with negative imaging findings need to be investigated further with an echo-guided liver biopsy or enhanced follow-up with imaging (every 3 months) to reach a final diagnosis. The cost-effectiveness ratio of surveillance depends on multiple factors, like HCC incidence, the cost and accuracy of diagnostic tests and the costs and outcome of the therapeutic interventions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1478-3231
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
29 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
143-7
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Screening and diagnosis of hepatocellular carcinoma.
pubmed:affiliation
A.M. & A. Migliavacca Center for Liver Diseases, 1st Division of Gastroenterology, Fondazione IRCCS Maggiore Hospital, Mangiagalli e Regina Elena, University of Milan, Milan, Italy. massimo.colombo@unimi.it
pubmed:publicationType
Journal Article, Review