19207594

Source:http://linkedlifedata.com/resource/pubmed/id/19207594

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0017296, umls-concept:C1280477
pubmed:issue	4
pubmed:dateCreated	2009-4-2
pubmed:abstractText	The liver is involved in the synthesis of serum proteins, regulation of metabolism and maintenance of homeostasis and provides a variety of opportunities for gene therapy. The enriched vasculature and blood circulation, fenestrated endothelium, abundant receptors on the plasma membranes of the liver cells, and effective transcription and translation machineries in the hepatocytes are some unique features that have been explored for delivery, and functional analysis, of genetic sequences in the liver. Both viral and non-viral methods have been developed for effective gene delivery and liver-based gene therapy. This review describes the fundamentals of gene delivery, and the preclinical and clinical progress that has been made toward gene therapy using the liver as a target.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9711801
pubmed:status	PubMed-not-MEDLINE
pubmed:month	Apr
pubmed:issn	1386-6346
pubmed:author	pubmed-author:AoyagiYutakaY, pubmed-author:DalyS MSM, pubmed-author:IgarashiMasatoM, pubmed-author:KamimuraKenyaK, pubmed-author:KawaiHirokazuH, pubmed-author:KubotaTomoyukiT, pubmed-author:SudaTakeshiT, pubmed-author:TamuraYasushiY
pubmed:issnType	Print
pubmed:volume	39
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	325-40
pubmed:year	2009
pubmed:articleTitle	Progress toward liver-based gene therapy.
pubmed:affiliation	Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Niigata, Japan.
pubmed:publicationType	Journal Article