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rdf:type |
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lifeskim:mentions |
umls-concept:C0011209,
umls-concept:C0015519,
umls-concept:C0040018,
umls-concept:C0079411,
umls-concept:C0087111,
umls-concept:C0181090,
umls-concept:C0183683,
umls-concept:C0205082,
umls-concept:C0302614,
umls-concept:C0344211,
umls-concept:C0456388,
umls-concept:C1171411,
umls-concept:C1317973,
umls-concept:C1521721,
umls-concept:C1524063,
umls-concept:C1706050
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pubmed:issue |
4
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pubmed:dateCreated |
2009-2-10
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pubmed:abstractText |
Severe FX deficiency is a rare disorder with a variable bleeding tendency but spontaneous life threatening haemorrhage can occur. Treatment for invasive procedures and spontaneous bleeding is with prothrombin complex concentrates (PCC). When used in large or repetitive doses these are associated with a thrombotic tendency. FX:C levels of 0.15 - 0.30 IU/ mL are thought to be haemostatic during surgery . There is only limited information on the outcome and management of pregnancy in severe FX deficiency. Caesarean section is suggested as delivery mode to reduce the risk of intracranial/abdominal neonatal haemorrhage, but successful vaginal deliveries are also described. The calibrated automated thrombin generation assay (CAT) is a global coagulation test that measures the time course of thrombin generation. It has been reported to correlate with prothrombotic states and the severity of bleeding in rare coagulation disorders. The variability in phenotype, the uncertainty of the minimal haemostatic FX:C concentration and the association of PCC's with thrombosis make thrombin generation of interest in the management of FX deficient patients.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19204776-10498586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19204776-10499904,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19204776-11775493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19204776-12134597,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19204776-12362226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19204776-12439153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19204776-12853707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19204776-13679651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19204776-15138162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19204776-15205589,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19204776-15347012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19204776-15357789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19204776-15357794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19204776-15550027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19204776-15735797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19204776-16011583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19204776-16411418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19204776-16488980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19204776-16868297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19204776-8192155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19204776-8841269
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pubmed:language |
eng
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pubmed:journal |
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pubmed:status |
PubMed-not-MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1723-2007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
204-9
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pubmed:year |
2007
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pubmed:articleTitle |
Blood product support for delivery in severe factor X deficiency: the use of thrombin generation to guide therapy.
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pubmed:affiliation |
Sheffield Haemophilia and Thrombosis Centre, Royal Hallamshire Hospital,Sheffield, United Kingdom.
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pubmed:publicationType |
Journal Article
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