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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2009-7-3
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pubmed:abstractText |
Using heterologous prime-boost (DNA immunization followed by immunization with transfected cells), we have generated depleting mouse anti-baboon CD2 monoclonal antibodies (mAb). These anti-CD2 mAb recognized a diverse range of primate CD2 from New World monkeys and Old World monkeys to humans and have potent immunosuppressive activity for human allo-MLR responses and anti-tetanus-toxoid recall responses. There was no upregulation of activation markers or release of cytokines when the mAb were incubated with human peripheral blood mononuclear cells. Using chimeric NOD-SCID IL2rgamma(null) mice, the mAb were shown to deplete human and cynomolgus monkey T cells in vivo. These anti-CD2 mAb may therefore be important immunological tools in allo- and xenotransplantation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD2,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/CD69 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2 Receptor alpha Subunit,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0818-9641
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
87
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
413-8
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:19204736-Animals,
pubmed-meshheading:19204736-Antibodies, Monoclonal,
pubmed-meshheading:19204736-Antigens, CD,
pubmed-meshheading:19204736-Antigens, CD2,
pubmed-meshheading:19204736-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:19204736-CHO Cells,
pubmed-meshheading:19204736-Callithrix,
pubmed-meshheading:19204736-Cell Proliferation,
pubmed-meshheading:19204736-Cricetinae,
pubmed-meshheading:19204736-Cricetulus,
pubmed-meshheading:19204736-Flow Cytometry,
pubmed-meshheading:19204736-Humans,
pubmed-meshheading:19204736-Interferon-gamma,
pubmed-meshheading:19204736-Interleukin-2,
pubmed-meshheading:19204736-Interleukin-2 Receptor alpha Subunit,
pubmed-meshheading:19204736-Lectins, C-Type,
pubmed-meshheading:19204736-Macaca fascicularis,
pubmed-meshheading:19204736-Macaca nemestrina,
pubmed-meshheading:19204736-Mice,
pubmed-meshheading:19204736-Mice, Inbred BALB C,
pubmed-meshheading:19204736-Mice, Inbred NOD,
pubmed-meshheading:19204736-Mice, Knockout,
pubmed-meshheading:19204736-Mice, SCID,
pubmed-meshheading:19204736-Papio hamadryas,
pubmed-meshheading:19204736-Phylogeny,
pubmed-meshheading:19204736-Primates,
pubmed-meshheading:19204736-T-Lymphocytes
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pubmed:year |
2009
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pubmed:articleTitle |
Monoclonal antibodies generated by DNA immunization recognize CD2 from a broad range of primates.
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pubmed:affiliation |
Division of Autoimmunity and Transplantation, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
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pubmed:publicationType |
Journal Article
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