Linked Life Data

19203544

Source:http://linkedlifedata.com/resource/pubmed/id/19203544

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2009-2-10
pubmed:abstractText
Although much has been learned regarding the pathogenesis of kidney stones, the reason(s) why some individuals form stones while others do not remains incompletely understood. Nanoparticles, which have been observed in geologic samples, have also been isolated from biologic specimens, including kidney stones. These nanoparticles have certain properties that are consistent with a novel life form, including in vitro self-replication, and contain lipids, DNA and proteins. Therefore, it has been hypothesized that nanoparticles may represent a type of infective agent that initiates stone formation in some individuals. Despite a large body of intriguing and suggestive evidence, the true biologic nature of these entities has been elusive, and controversy remains as to whether these nano-sized particles are analogous to other recently described unusual and novel microorganisms, or a transmissible, yet inert nanoparticle. Although unique DNA or RNA has yet to be identified, a proteomic biosignature is beginning to emerge that may allow more definitive clinical investigation. This review evaluates the current evidence regarding nanoparticles as causal to disease and emphasizes the need for additional research to further elucidate their role in human stone formation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0301-0430
pubmed:author
pubmed:issnType
Print
pubmed:volume
71
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-8
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Do calcifying nanoparticles promote nephrolithiasis? A review of the evidence.
pubmed:affiliation
Departments of Internal Medicine, Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't