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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1991-11-18
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pubmed:abstractText |
Seven analogues of 3-quinuclidinyl benzilate (QNB) in which one phenyl ring was replaced by an alkoxyalkyl moiety were synthesized and their affinities for the muscarinic cholinergic receptor determined. An oxygen in the beta-position of the moiety was not well-tolerated. By contrast, an oxygen in the gamma-position did not change the affinity for the muscarinic receptor. However, when a bromine was placed on the remaining phenyl ring, the affinity was significantly reduced in striking contrast to results obtained on halogenation of QNB.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-2623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
34
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2989-93
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:1920351-Animals,
pubmed-meshheading:1920351-Bromine,
pubmed-meshheading:1920351-Corpus Striatum,
pubmed-meshheading:1920351-Iodine Radioisotopes,
pubmed-meshheading:1920351-Male,
pubmed-meshheading:1920351-Molecular Structure,
pubmed-meshheading:1920351-Quinuclidinyl Benzilate,
pubmed-meshheading:1920351-Rats,
pubmed-meshheading:1920351-Rats, Inbred Strains,
pubmed-meshheading:1920351-Receptors, Muscarinic,
pubmed-meshheading:1920351-Structure-Activity Relationship
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pubmed:year |
1991
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pubmed:articleTitle |
Synthesis and muscarinic cholinergic receptor affinities of 3-quinuclidinyl alpha-(alkoxyalkyl)-alpha-aryl-alpha-hydroxyacetates.
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pubmed:affiliation |
Section of Radiopharmaceutical Chemistry, George Washington University Medical Center, Washington, D.C. 20037.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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