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pubmed-article:1920342pubmed:abstractTextIn this randomised double-blind parallel study, we compared the efficacy of labetalol and atenolol in a group of black (n = 33) and white (n = 34) hypertensives with uncomplicated essential hypertension after obtaining pretreatment renin profiles. After single-blind placebo (14-21 days), patients with standing diastolic BP between 105-119 mmHg were randomised to receive either labetalol (100-800 mg twice daily) or atenolol (50-100 mg once daily) to achieve a DBP less than 90 mmHg. Dosage titration occurred at weekly intervals for labetalol and biweekly for atenolol. The supine BP decrease with atenolol was -18/-14 vs. -6/-6 mmHg in whites vs. blacks respectively. With labetalol, it was -13/-12 in whites and -2/-7 mmHg in blacks. Standing BPs were: -19/-14 vs. -4/-5, whites vs. blacks with atenolol and -17/-17 vs. -19/-9 mmHg with labetalol. Neither labetalol nor atenolol was as effective in black compared with white hypertensives. The atenolol but not labetalol BP response was positively correlated with pretreatment renin values.lld:pubmed
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pubmed-article:1920342pubmed:authorpubmed-author:WrightJ TJTJrlld:pubmed
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pubmed-article:1920342pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:1920342pubmed:articleTitleRenin profile, race, and antihypertensive efficacy with atenolol and labetalol.lld:pubmed
pubmed-article:1920342pubmed:affiliationDepartment of Medicine, Medical College of Virginia, Commonwealth University, Richmond.lld:pubmed
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