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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1991-11-4
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pubmed:abstractText |
In this randomised double-blind parallel study, we compared the efficacy of labetalol and atenolol in a group of black (n = 33) and white (n = 34) hypertensives with uncomplicated essential hypertension after obtaining pretreatment renin profiles. After single-blind placebo (14-21 days), patients with standing diastolic BP between 105-119 mmHg were randomised to receive either labetalol (100-800 mg twice daily) or atenolol (50-100 mg once daily) to achieve a DBP less than 90 mmHg. Dosage titration occurred at weekly intervals for labetalol and biweekly for atenolol. The supine BP decrease with atenolol was -18/-14 vs. -6/-6 mmHg in whites vs. blacks respectively. With labetalol, it was -13/-12 in whites and -2/-7 mmHg in blacks. Standing BPs were: -19/-14 vs. -4/-5, whites vs. blacks with atenolol and -17/-17 vs. -19/-9 mmHg with labetalol. Neither labetalol nor atenolol was as effective in black compared with white hypertensives. The atenolol but not labetalol BP response was positively correlated with pretreatment renin values.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
|
pubmed:issn |
0950-9240
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
5
|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
193-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1920342-African Continental Ancestry Group,
pubmed-meshheading:1920342-Atenolol,
pubmed-meshheading:1920342-Blood Pressure,
pubmed-meshheading:1920342-Double-Blind Method,
pubmed-meshheading:1920342-European Continental Ancestry Group,
pubmed-meshheading:1920342-Humans,
pubmed-meshheading:1920342-Hypertension,
pubmed-meshheading:1920342-Labetalol,
pubmed-meshheading:1920342-Middle Aged,
pubmed-meshheading:1920342-Renin
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pubmed:year |
1991
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pubmed:articleTitle |
Renin profile, race, and antihypertensive efficacy with atenolol and labetalol.
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pubmed:affiliation |
Department of Medicine, Medical College of Virginia, Commonwealth University, Richmond.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial
|