| pubmed-article:19201909 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19201909 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:19201909 | lifeskim:mentions | umls-concept:C0030498 | lld:lifeskim |
| pubmed-article:19201909 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:19201909 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:19201909 | lifeskim:mentions | umls-concept:C0023283 | lld:lifeskim |
| pubmed-article:19201909 | lifeskim:mentions | umls-concept:C1420306 | lld:lifeskim |
| pubmed-article:19201909 | lifeskim:mentions | umls-concept:C0162388 | lld:lifeskim |
| pubmed-article:19201909 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:19201909 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:19201909 | pubmed:dateCreated | 2009-2-9 | lld:pubmed |
| pubmed-article:19201909 | pubmed:abstractText | Type I IFNs (IFN-alpha/beta) have only recently gained considerable attention as immunomodulators in nonviral infectious diseases. IFN-beta has been shown to protect, in a NO-dependent manner, against murine Old World leishmaniasis caused by Leishmania major, but data in New World leishmaniasis are lacking. We found that IFN-beta dose-dependently increases parasite burden in Leishmania amazonensis- as well as Leishmania braziliensis-infected human macrophages, independent of endogenous or exogenous NO. However, IFN-beta significantly reduced superoxide release in Leishmania-infected as well as uninfected human macrophages. This decrease in superoxide production was paralleled by a significant IFN-beta-mediated increase in superoxide dismutase 1 (SOD1) protein levels. Additionally, IFN-beta inhibition of leishmanicidal activity was mimicked by SOD1 and antagonized by either pharmacological or small interfering RNA-mediated inhibition of SOD1. Finally, pronounced SOD1 expression in situ was demonstrated in biopsies from New World cutaneous leishmaniasis patients. These findings reveal a hitherto unknown IFN-beta/SOD1 axis in Leishmania infection and suggest that inhibition of SOD-associated pathways could serve as strategy in the treatment of L. amazonensis as well as L. braziliensis infection, major human pathogens. | lld:pubmed |
| pubmed-article:19201909 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19201909 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19201909 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:19201909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19201909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19201909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19201909 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19201909 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:19201909 | pubmed:issn | 1550-6606 | lld:pubmed |
| pubmed-article:19201909 | pubmed:author | pubmed-author:Barral-NettoM... | lld:pubmed |
| pubmed-article:19201909 | pubmed:author | pubmed-author:WietzerbinJua... | lld:pubmed |
| pubmed-article:19201909 | pubmed:author | pubmed-author:BarralAldinaA | lld:pubmed |
| pubmed-article:19201909 | pubmed:author | pubmed-author:Van... | lld:pubmed |
| pubmed-article:19201909 | pubmed:author | pubmed-author:KolbJean-Pier... | lld:pubmed |
| pubmed-article:19201909 | pubmed:author | pubmed-author:BaficaAndréA | lld:pubmed |
| pubmed-article:19201909 | pubmed:author | pubmed-author:KhouriRicardo... | lld:pubmed |
| pubmed-article:19201909 | pubmed:author | pubmed-author:SilvaMaria... | lld:pubmed |
| pubmed-article:19201909 | pubmed:author | pubmed-author:NoronhaAlmeri... | lld:pubmed |
| pubmed-article:19201909 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19201909 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:19201909 | pubmed:volume | 182 | lld:pubmed |
| pubmed-article:19201909 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19201909 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19201909 | pubmed:pagination | 2525-31 | lld:pubmed |
| pubmed-article:19201909 | pubmed:meshHeading | pubmed-meshheading:19201909... | lld:pubmed |
| pubmed-article:19201909 | pubmed:meshHeading | pubmed-meshheading:19201909... | lld:pubmed |
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| pubmed-article:19201909 | pubmed:meshHeading | pubmed-meshheading:19201909... | lld:pubmed |
| pubmed-article:19201909 | pubmed:meshHeading | pubmed-meshheading:19201909... | lld:pubmed |
| pubmed-article:19201909 | pubmed:meshHeading | pubmed-meshheading:19201909... | lld:pubmed |
| pubmed-article:19201909 | pubmed:meshHeading | pubmed-meshheading:19201909... | lld:pubmed |
| pubmed-article:19201909 | pubmed:meshHeading | pubmed-meshheading:19201909... | lld:pubmed |
| pubmed-article:19201909 | pubmed:meshHeading | pubmed-meshheading:19201909... | lld:pubmed |
| pubmed-article:19201909 | pubmed:meshHeading | pubmed-meshheading:19201909... | lld:pubmed |
| pubmed-article:19201909 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19201909 | pubmed:articleTitle | IFN-beta impairs superoxide-dependent parasite killing in human macrophages: evidence for a deleterious role of SOD1 in cutaneous leishmaniasis. | lld:pubmed |
| pubmed-article:19201909 | pubmed:affiliation | Laboratory of Immunoregulation and Microbiology, Centro de Pesquisa Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador- Bahia, Brazi. | lld:pubmed |
| pubmed-article:19201909 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19201909 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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