Source:http://linkedlifedata.com/resource/pubmed/id/19201909
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2009-2-9
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pubmed:abstractText |
Type I IFNs (IFN-alpha/beta) have only recently gained considerable attention as immunomodulators in nonviral infectious diseases. IFN-beta has been shown to protect, in a NO-dependent manner, against murine Old World leishmaniasis caused by Leishmania major, but data in New World leishmaniasis are lacking. We found that IFN-beta dose-dependently increases parasite burden in Leishmania amazonensis- as well as Leishmania braziliensis-infected human macrophages, independent of endogenous or exogenous NO. However, IFN-beta significantly reduced superoxide release in Leishmania-infected as well as uninfected human macrophages. This decrease in superoxide production was paralleled by a significant IFN-beta-mediated increase in superoxide dismutase 1 (SOD1) protein levels. Additionally, IFN-beta inhibition of leishmanicidal activity was mimicked by SOD1 and antagonized by either pharmacological or small interfering RNA-mediated inhibition of SOD1. Finally, pronounced SOD1 expression in situ was demonstrated in biopsies from New World cutaneous leishmaniasis patients. These findings reveal a hitherto unknown IFN-beta/SOD1 axis in Leishmania infection and suggest that inhibition of SOD-associated pathways could serve as strategy in the treatment of L. amazonensis as well as L. braziliensis infection, major human pathogens.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-beta,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxide Dismutase,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxides,
http://linkedlifedata.com/resource/pubmed/chemical/superoxide dismutase 1
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1550-6606
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pubmed:author |
pubmed-author:BaficaAndréA,
pubmed-author:Barral-NettoManoelM,
pubmed-author:BarralAldinaA,
pubmed-author:KhouriRicardoR,
pubmed-author:KolbJean-PierreJP,
pubmed-author:NoronhaAlmerioA,
pubmed-author:SilvaMaria da Purificação PereiraMda P,
pubmed-author:Van WeyenberghJohanJ,
pubmed-author:WietzerbinJuanaJ
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
182
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2525-31
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pubmed:meshHeading |
pubmed-meshheading:19201909-Cells, Cultured,
pubmed-meshheading:19201909-Humans,
pubmed-meshheading:19201909-Immunohistochemistry,
pubmed-meshheading:19201909-Interferon-beta,
pubmed-meshheading:19201909-Leishmaniasis, Cutaneous,
pubmed-meshheading:19201909-Macrophages,
pubmed-meshheading:19201909-Nitric Oxide,
pubmed-meshheading:19201909-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:19201909-Superoxide Dismutase,
pubmed-meshheading:19201909-Superoxides
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pubmed:year |
2009
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pubmed:articleTitle |
IFN-beta impairs superoxide-dependent parasite killing in human macrophages: evidence for a deleterious role of SOD1 in cutaneous leishmaniasis.
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pubmed:affiliation |
Laboratory of Immunoregulation and Microbiology, Centro de Pesquisa Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador- Bahia, Brazi.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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