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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2009-10-16
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pubmed:abstractText |
Activated hepatic stellate cells (HSCs) but not quiescent HSCs express cyclo-oxygenase-2 (COX-2), suggesting that the COX-2/prostanoid pathway has an active role in hepatic fibrogenesis. However, the role of COX-2 inhibitors in hepatic fibrogenesis remains controversial. The aim of this study was to investigate the antifibrotic effects of celecoxib, a selective COX-2 inhibitor.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1468-3288
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pubmed:author |
pubmed-author:AnS HSH,
pubmed-author:BrennerD ADA,
pubmed-author:ChoyC TCT,
pubmed-author:KangS HSH,
pubmed-author:KimD YDY,
pubmed-author:KimJ KJK,
pubmed-author:LeeD KDK,
pubmed-author:LeeJ IJI,
pubmed-author:LeeK SKS,
pubmed-author:LeeS ISI,
pubmed-author:LeeS JSJ,
pubmed-author:ORRR JRJ,
pubmed-author:PaikY-HYH
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pubmed:issnType |
Electronic
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pubmed:volume |
58
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1517-27
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pubmed:meshHeading |
pubmed-meshheading:19201774-Animals,
pubmed-meshheading:19201774-Apoptosis,
pubmed-meshheading:19201774-Cells, Cultured,
pubmed-meshheading:19201774-Cyclooxygenase Inhibitors,
pubmed-meshheading:19201774-Hepatic Stellate Cells,
pubmed-meshheading:19201774-Humans,
pubmed-meshheading:19201774-Liver Cirrhosis, Experimental,
pubmed-meshheading:19201774-Male,
pubmed-meshheading:19201774-Pyrazoles,
pubmed-meshheading:19201774-Rats,
pubmed-meshheading:19201774-Sulfonamides
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pubmed:year |
2009
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pubmed:articleTitle |
Celecoxib induces hepatic stellate cell apoptosis through inhibition of Akt activation and suppresses hepatic fibrosis in rats.
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pubmed:affiliation |
Department of Internal Medicine, Institute of Gastroenterology, Brain Korea 21 Project for Medical Science, Liver Cirrhosis Clinical Research Center, Yonsei University College of Medicine, Seoul 135-720, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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