Source:http://linkedlifedata.com/resource/pubmed/id/19201635
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2009-5-11
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| pubmed:abstractText |
The World Health Organization fracture risk assessment tool (FRAX) uses clinical risk factors to predict the patient's 10-yr probability of sustaining a hip or other major osteoporosis-related fracture. Inclusion of the femoral neck T-score is optional in the calculation. We evaluated the impact of including the T-score in the calculation of fracture risk and resultant treatment recommendation. We retrospectively reviewed charts of 180 white women scanned on a Hologic dual-energy X-ray absorptiometry (DXA). FRAX scores were calculated with T-scores (FRAX+) and without T-scores (FRAX-). We compared the National Osteoporosis Foundation (NOF) treatment recommendations (>or=20% risk of a major osteoporotic fracture or >or=3% risk of hip fracture for osteopenic patients) between FRAX+ and FRAX- scores. Agreement between FRAX+ and FRAX- was 89.4%. Disagreement occurred in 2 distinct subgroups of patients (10.6% of cases), that is, FRAX+ scores exceeded the NOF recommended treatment thresholds and FRAX- scores did not, or vice versa. One subgroup comprised older patients with normal T-scores for whom FRAX- scores exceeded the treatment threshold. The second subgroup comprised younger patients with high body mass index (BMI) and low T-scores for whom FRAX- scores did not exceed the treatment threshold. FRAX scores generated without T-scores may lead to treatment recommendations for patients who have normal bone mineral density and no treatment recommendations for patients who have osteoporosis. T-scores should be used for optimal application of FRAX.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:issn |
1094-6950
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
12
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
158-61
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| pubmed:meshHeading |
pubmed-meshheading:19201635-Absorptiometry, Photon,
pubmed-meshheading:19201635-Aged,
pubmed-meshheading:19201635-Bone Density,
pubmed-meshheading:19201635-European Continental Ancestry Group,
pubmed-meshheading:19201635-Female,
pubmed-meshheading:19201635-Femur,
pubmed-meshheading:19201635-Fractures, Bone,
pubmed-meshheading:19201635-Humans,
pubmed-meshheading:19201635-Middle Aged,
pubmed-meshheading:19201635-Osteoporosis,
pubmed-meshheading:19201635-Probability,
pubmed-meshheading:19201635-Risk Assessment
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| pubmed:articleTitle |
Variance in 10-year fracture risk calculated with and without T-scores in select subgroups of normal and osteoporotic patients.
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| pubmed:affiliation |
Osteoporosis Center, East Tennessee State University, Johnson City, TN, USA; VAMC, Johnson City, TN, USA.
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| pubmed:publicationType |
Journal Article
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