Source:http://linkedlifedata.com/resource/pubmed/id/19201604
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
2009-2-23
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pubmed:abstractText |
A number of N-substituted cyclic imides 3a-e, 5a-e, 7a-d, and 9a-e have been synthesized in very high yields, by condensation of various diacids 2, 4, 6, and 8 with different amines under microwave irradiation. These compounds were screened for anticancer and anti-inflammatory activities, and compounds 3c, 3e, 5c, 9c, and 9d exhibited anticancer activity against colon (COLO 205) cancer better than 5-fluorouracil and mitomycin-C, and compound 9b exhibited anti-inflammatory activity better than standard drug phenyl butazone.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1464-3405
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1534-8
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pubmed:meshHeading |
pubmed-meshheading:19201604-Animals,
pubmed-meshheading:19201604-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:19201604-Antineoplastic Agents,
pubmed-meshheading:19201604-Cell Line, Tumor,
pubmed-meshheading:19201604-Drug Evaluation, Preclinical,
pubmed-meshheading:19201604-Edema,
pubmed-meshheading:19201604-Female,
pubmed-meshheading:19201604-Humans,
pubmed-meshheading:19201604-Imides,
pubmed-meshheading:19201604-Male,
pubmed-meshheading:19201604-Microwaves,
pubmed-meshheading:19201604-Rats
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pubmed:year |
2009
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pubmed:articleTitle |
Microwave-assisted synthesis of N-substituted cyclic imides and their evaluation for anticancer and anti-inflammatory activities.
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pubmed:affiliation |
Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee, Uttaranchal 247667, India.
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pubmed:publicationType |
Journal Article,
Comparative Study
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