Linked Life Data

19201544

Source:http://linkedlifedata.com/resource/pubmed/id/19201544

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2009-3-4
pubmed:abstractText
Graft-versus-host disease (GVHD) is a lethal complication of allogeneic hematopoietic stem cell transplantation where activated donor T cells attack the genetically disparate host cells. The main target organs of the T cells in GVHD are the skin, liver, and intestine. In order to explain why the lung, one of the barrier organs, is spared from the injury of effector T cells, we hypothesize that endothelial cells are essential for immune regulation in acute GVHD. The proposed mechanism including Th1 cells apoptosis induced by endothelial cells expressing Tim-3 ligand galectin-9, and differential expression levels of galectin-9 on endothelial cells in various organs. The elucidation of the detailed cellular and molecular mechanisms that involved may help to a better understanding of immunoregulation in acute GVHD. Furthermore, the hypothesis may offer improved insight into new therapeutic strategy to reduce the severity of GVHD.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1532-2777
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
72
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
567-9
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Endothelial cells: a novel key player in immunoregulation in acute graft-versus-host disease?
pubmed:affiliation
Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
pubmed:publicationType
Journal Article