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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
25-26
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pubmed:dateCreated |
2009-5-22
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pubmed:abstractText |
We have developed a novel tuberculosis (TB) vaccine; a combination of the DNA vaccines expressing mycobacterial heat shock protein 65 (HSP65) and interleukin 12 (IL-12) delivered by the hemagglutinating virus of Japan (HVJ)-envelope and -liposome (HSP65+IL-12/HVJ). This vaccine provided therapeutic efficacy as well as remarkable protective efficacy via CD8(+) T and CD4(+) T cells in murine models compared with the saline controls, on the basis of CFU of number of multi-drug resistant TB (MDR-TB), and survival of extremely drug resistant TB (XDR-TB) challenged mice. Furthermore, we extended our studies to a cynomolgus monkey model, which is currently the best animal model of human tuberculosis. This vaccine exerted therapeutic efficacy (survival and immune responses) in the TB-infected monkeys. These data indicate that our novel DNA vaccine might be useful against Mycobacterium tuberculosis including XDR-TB and MDR-TB for human therapeutic clinical trials.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Chaperonin 60,
http://linkedlifedata.com/resource/pubmed/chemical/Chaperonins,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-12,
http://linkedlifedata.com/resource/pubmed/chemical/Tuberculosis Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Vaccines, DNA,
http://linkedlifedata.com/resource/pubmed/chemical/heat-shock protein 65, Mycobacterium
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0264-410X
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pubmed:author |
pubmed-author:AbalosR MRM,
pubmed-author:BurgosJ AJA,
pubmed-author:Dela CruzE CEC,
pubmed-author:HashimotoSatomiS,
pubmed-author:InoueYoshikazuY,
pubmed-author:KanamaruNorikoN,
pubmed-author:KanedaYasufumiY,
pubmed-author:KishigamiChieC,
pubmed-author:KitaYokoY,
pubmed-author:MatsumotoMakotoM,
pubmed-author:McMurrayDavid NDN,
pubmed-author:NagasawaTetsujiT,
pubmed-author:NakajimaToshihiroT,
pubmed-author:NakataniHitoshiH,
pubmed-author:NishidaYasukoY,
pubmed-author:OkadaMasajiM,
pubmed-author:SakataniMitsunoriM,
pubmed-author:SaundersonPaulP,
pubmed-author:TakaoKyokoK,
pubmed-author:YeeJ YJY,
pubmed-author:YoshidaShigetoS
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pubmed:issnType |
Print
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pubmed:day |
26
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3267-70
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:19200841-Animals,
pubmed-meshheading:19200841-Antigens, CD8,
pubmed-meshheading:19200841-Bacterial Proteins,
pubmed-meshheading:19200841-Chaperonin 60,
pubmed-meshheading:19200841-Chaperonins,
pubmed-meshheading:19200841-Drug Resistance, Multiple, Bacterial,
pubmed-meshheading:19200841-Interleukin-12,
pubmed-meshheading:19200841-Lung,
pubmed-meshheading:19200841-Macaca fascicularis,
pubmed-meshheading:19200841-Mice,
pubmed-meshheading:19200841-Tuberculosis,
pubmed-meshheading:19200841-Tuberculosis Vaccines,
pubmed-meshheading:19200841-Vaccination,
pubmed-meshheading:19200841-Vaccines, DNA
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pubmed:year |
2009
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pubmed:articleTitle |
Novel prophylactic and therapeutic vaccine against tuberculosis.
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pubmed:affiliation |
Clinical Research Center, National Hospital Organization Kinki-chuo Chest Medical Center, 1180 Nagasone, Kitaku, Sakai, Osaka 591-8555, Japan. okm@kch.hosp.go.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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