Source:http://linkedlifedata.com/resource/pubmed/id/19200605
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2009-3-17
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pubmed:abstractText |
Preeclampsia is a disease associated with the maternal inflammatory response. YKL-40 and interleukin-18 (IL-18) are inflammatory markers involved in inflammatory states and vascular processes. The aim of this study was to evaluate serum levels of YKL-40 and IL-18 in preeclampsia. Twenty-four patients with preeclampsia and 13 healthy pregnant women were included in this study. Serum levels of YKL-40 and IL-18 were measured using an enzyme-linked immunosorbent assay (ELISA). Serum YKL-40 levels were significantly higher in patients with preeclampsia (median 75.0 ng/mL; range 45.8-125.4 ng/mL) than in normal pregnant women (median 29.3 ng/mL; range 16.2-39.5 ng/mL; p=0.000). Serum IL-18 levels were also significantly higher in patients with preeclampsia (median 159.9 pg/mL; range 125.6-193.5 pg/mL) than in normal pregnant women (median 120.2 pg/mL; range 102.2-157.9 pg/mL; p=0.018). Notably, higher serum YKL-40 levels were observed in patients with more severe proteinuria (>or=3+ by dipstick) than in patients with milder proteinuria (<or=1+ by dipstick; median 121.3 ng/mL, range 63.5-146.7 ng/mL versus median 55.4 ng/mL, range 29.4-116.3 ng/mL; p=0.022). There was, however, no significant difference in serum IL-18 levels between patients with more severe proteinuria and those with milder proteinuria. We conclude that circulating YKL-40 and IL-18 are elevated in patients with preeclampsia, and levels of YKL-40 are related to the severity of the disease.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adipokines,
http://linkedlifedata.com/resource/pubmed/chemical/CHI3L1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-18,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1872-7603
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
79
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
183-7
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19200605-Adipokines,
pubmed-meshheading:19200605-Adult,
pubmed-meshheading:19200605-Case-Control Studies,
pubmed-meshheading:19200605-Female,
pubmed-meshheading:19200605-Glycoproteins,
pubmed-meshheading:19200605-Health,
pubmed-meshheading:19200605-Humans,
pubmed-meshheading:19200605-Inflammation,
pubmed-meshheading:19200605-Interleukin-18,
pubmed-meshheading:19200605-Lectins,
pubmed-meshheading:19200605-Pre-Eclampsia,
pubmed-meshheading:19200605-Pregnancy,
pubmed-meshheading:19200605-Proteinuria
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pubmed:year |
2009
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pubmed:articleTitle |
Serum levels of YKL-40 and interleukin-18 and their relationship to disease severity in patients with preeclampsia.
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pubmed:affiliation |
Department of Obstetrics and Gynecology, College of Medicine, Korea University, Seoul, Republic of Korea.
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pubmed:publicationType |
Journal Article
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