Linked Life Data

19200025

Source:http://linkedlifedata.com/resource/pubmed/id/19200025

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-2-9
pubmed:abstractText
Malaria, perhaps one of the most serious and widespread diseases encountered by mankind, continues to be a major threat to about 40 % of the world's population, especially in the developing world. As malaria vaccines remain problematic, chemotherapy still is the most important weapon in the fight against the disease. However, almost all available drugs have been compromised by the highly adaptable parasite, and the increasing drug resistance of Plasmodium falciparum continues to be the main problem. Therefore, the limited clinical repertoire of effective drugs and the emergence of multi-resistant strains substantiate the need for new anti-malarials. Plant-derived artemisinin is currently the only available drug that is globally effective, but alarmingly, recent studies suggest that resistance already may be developing. Nevertheless, the success story of artemisinin from the herb Qing Hao (Artemisia annua L.), used as a remedy in traditional Chinese medicine for more than two thousand years, shows once again that natural products serve as an invaluable reservoir of lead compounds for sophisticated small molecules. This review outlines the major anti-malarials, summarizing recent knowledge about their mode of action and the development of drug resistance. Furthermore, the most promising and recently discovered natural products with anti-malarial potential will be introduced.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1389-5575
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
206-2124
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Drug resistance in Plasmodium: natural products in the fight against malaria.
pubmed:affiliation
German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
pubmed:publicationType
Journal Article, Review