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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2009-2-27
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pubmed:abstractText |
Chemotherapy with indisulam causes myelosuppression. This study aimed to evaluate the influence of patient-related covariates on pharmacokinetics and pharmacodynamics, to identify patients at risk for severe myelosuppression and to develop a dosing algorithm for treatment optimization.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1573-8744
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
39-62
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pubmed:meshHeading |
pubmed-meshheading:19199010-Adult,
pubmed-meshheading:19199010-Aged,
pubmed-meshheading:19199010-Aged, 80 and over,
pubmed-meshheading:19199010-Algorithms,
pubmed-meshheading:19199010-Antineoplastic Agents,
pubmed-meshheading:19199010-Body Surface Area,
pubmed-meshheading:19199010-Clinical Trials as Topic,
pubmed-meshheading:19199010-Computer Simulation,
pubmed-meshheading:19199010-Continental Population Groups,
pubmed-meshheading:19199010-Cytochrome P-450 Enzyme System,
pubmed-meshheading:19199010-Cytotoxins,
pubmed-meshheading:19199010-Female,
pubmed-meshheading:19199010-Hematologic Diseases,
pubmed-meshheading:19199010-Humans,
pubmed-meshheading:19199010-Male,
pubmed-meshheading:19199010-Middle Aged,
pubmed-meshheading:19199010-Models, Biological,
pubmed-meshheading:19199010-Models, Statistical,
pubmed-meshheading:19199010-Neutropenia,
pubmed-meshheading:19199010-Risk,
pubmed-meshheading:19199010-Risk Factors,
pubmed-meshheading:19199010-Sex Factors,
pubmed-meshheading:19199010-Sulfonamides,
pubmed-meshheading:19199010-Thrombocytopenia,
pubmed-meshheading:19199010-Young Adult
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pubmed:year |
2009
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pubmed:articleTitle |
Covariate-based dose individualization of the cytotoxic drug indisulam to reduce the risk of severe myelosuppression.
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pubmed:affiliation |
Department of Pharmacy and Pharmacology, The Netherlands Cancer Institute/Slotervaart Hospital, Amsterdam, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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