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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2009-2-25
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pubmed:abstractText |
We identify the SLC22A3-LPAL2-LPA gene cluster as a strong susceptibility locus for coronary artery disease (CAD) through a genome-wide haplotype association (GWHA) study. This locus was not identified from previous genome-wide association (GWA) studies focused on univariate analyses of SNPs. The proposed approach may have wide utility for analyzing GWA data for other complex traits.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1546-1718
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pubmed:author |
pubmed-author:ArveilerDominiqueD,
pubmed-author:BallStephen GSG,
pubmed-author:BalmforthAnthony JAJ,
pubmed-author:BraundPeter SPS,
pubmed-author:BugertPeterP,
pubmed-author:CambienFrancoisF,
pubmed-author:Cardiogenics Consortium,
pubmed-author:DeSuremainMaylisM,
pubmed-author:El MokhtariNour ENE,
pubmed-author:ErdmannJeanetteJ,
pubmed-author:EvansAlunA,
pubmed-author:GermainCécileC,
pubmed-author:GrosshennigAnikaA,
pubmed-author:HallAlistair SAS,
pubmed-author:HengstenbergChristianC,
pubmed-author:KönigInke RIR,
pubmed-author:Linsel-NitschkePatrickP,
pubmed-author:LucGéraldG,
pubmed-author:MeisingerChristaC,
pubmed-author:MeitingerThomasT,
pubmed-author:MorrisonCarolineC,
pubmed-author:MunteanuAlexandruA,
pubmed-author:NeureutherKatharinaK,
pubmed-author:OuwehandWillemW,
pubmed-author:PerretClaireC,
pubmed-author:PreussMichaelM,
pubmed-author:RubinDianaD,
pubmed-author:RuidavetsJean-BernardJB,
pubmed-author:SamaniNilesh JNJ,
pubmed-author:SchäferArneA,
pubmed-author:SchreiberStefanS,
pubmed-author:SchrezenmeirJürgenJ,
pubmed-author:SchunkertHeribertH,
pubmed-author:StarkKlausK,
pubmed-author:ThompsonJohn RJR,
pubmed-author:TiretLaurenceL,
pubmed-author:TrégouëtDavid-AlexandreDA,
pubmed-author:Wellcome Trust Case Control Consortium,
pubmed-author:WichmannH-ErichHE,
pubmed-author:WrightBen JBJ,
pubmed-author:ZieglerAndreasA,
pubmed-author:van der HarstPimP
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pubmed:issnType |
Electronic
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
283-5
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pubmed:meshHeading |
pubmed-meshheading:19198611-Apolipoprotein A-II,
pubmed-meshheading:19198611-Case-Control Studies,
pubmed-meshheading:19198611-Coronary Artery Disease,
pubmed-meshheading:19198611-Gene Frequency,
pubmed-meshheading:19198611-Genetic Predisposition to Disease,
pubmed-meshheading:19198611-Genome-Wide Association Study,
pubmed-meshheading:19198611-Haplotypes,
pubmed-meshheading:19198611-Humans,
pubmed-meshheading:19198611-Lipoprotein(a),
pubmed-meshheading:19198611-Multigene Family,
pubmed-meshheading:19198611-Organic Cation Transport Proteins,
pubmed-meshheading:19198611-Polymorphism, Single Nucleotide,
pubmed-meshheading:19198611-Quantitative Trait Loci,
pubmed-meshheading:19198611-Risk Factors
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pubmed:year |
2009
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pubmed:articleTitle |
Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease.
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pubmed:affiliation |
Institut National de la Santé Et de la Recherche Médicale (INSERM) Unité Mixte de Recherche (UMR_S) 525, Université Pierre et Marie Curie (UPMC). Paris 06, Paris 75013, France. david.tregouet@upmc.fr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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