Linked Life Data

19198457

Source:http://linkedlifedata.com/resource/pubmed/id/19198457

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2009-2-9
pubmed:abstractText
The toxic effect of nano and micron sized silica particle was studied on mice. The size of the nano and micron sized silica were approximately 30 nm and approximately 30 microm, respectively. The mice, Balb/c (20 approximately 30 g, white) and C57BL/6J (black) for the experiment were classified to normal, nano sized silica (1%), and micron sized silica (1%) dieted groups. After feeding for 10 weeks, the blood was tested biochemically and hematologically. There was no difference between the groups in the tested items except ALT (Alanine Aminotransferase). The nano sized silica particle dieted group showed higher value of ALT than normal and micron sized silica dieted groups. H&E staining of the liver of the nano sized particle dieted group indicated some fatty liver pattern while the contents of Si in the livers of the groups were almost the same. From the results, it was suggested that the nano sized silica particle had a toxic effect on the liver even though there was no significant different on the health in total fed amount of 140 g silica/kg mouse.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1533-4880
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5367-71
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Effect of micro/nano silica particle feeding for mice.
pubmed:affiliation
Department of Chemistry and NTRC, Chonnam National Universtiy, Gwangju 500-757, Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't